Gene: HNRNPLL
Official Full Name: heterogeneous nuclear ribonucleoprotein L likeprovided by HGNC
Gene Summary: HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05414 | HNRNPLL Knockout cell line (HeLa) | Human | HNRNPLL | 1:3~1:6 | Negative | Online Inquiry |
KO05415 | HNRNPLL Knockout cell line (HCT 116) | Human | HNRNPLL | 1:2~1:4 | Negative | Online Inquiry |
KO05416 | HNRNPLL Knockout cell line (HEK293) | Human | HNRNPLL | 1:3~1:6 | Negative | Online Inquiry |
KO05417 | HNRNPLL Knockout cell line (A549) | Human | HNRNPLL | 1:3~1:4 | Negative | Online Inquiry |
The HNRNPLL Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the heterogenous nuclear ribonucleoprotein L-like (HNRNPLL) gene. This system serves as a critical tool for researchers studying gene regulation, RNA processing, and the cellular machinery involved in mRNA metabolism. By targeting and knocking out the HNRNPLL gene, these cell lines allow scientists to investigate the role of HNRNPLL in various biological processes, such as alternative splicing, gene transcription regulation, and responses to cellular stress.
The cornerstone of the functionality of HNRNPLL Gene Knockout Cell Lines lies in their ability to provide a clean and precise model for evaluating HNRNPLL's contributions to cellular pathways. This is facilitated through various molecular techniques that assess changes in RNA levels, protein interactions, and phenotypic outcomes, offering insights that are pivotal for understanding diseases where HNRNPLL may play a role, such as cancers and neurodegenerative disorders. The knockout model is complemented by standardized protocols, ensuring reproducibility and reliability in experimental outcomes.
The scientific importance of HNRNPLL Gene Knockout Cell Lines extends into both research and clinical settings, driving forward the boundaries of molecular biology. Notably, they can be utilized to validate therapeutic targets or explore potential biomarkers, thereby enhancing drug discovery efforts. In comparison to conventional cell lines, these knockout models provide enhanced specificity and focus on the crucial role of HNRNPLL, circumventing confounding results commonly associated with wild-type cells.
In terms of value, the HNRNPLL Gene Knockout Cell Lines are indispensable for researchers and clinicians seeking to unravel the complexities of RNA biology and its implications in health and disease. Their unique capabilities foster a deeper understanding of molecular pathways, ultimately contributing to the advancement of precision medicine. By leveraging robust scientific evidence and rigorous validation, our company, with its dedication to delivering high-quality biological research tools, offers these specialized cell lines as a testament to our commitment to supporting innovation and discovery in the life sciences field.
Please note that all services are for research use only. Not intended for any clinical use.
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