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HNRNPAB Knockout Cell Lines

Gene: HNRNPAB

Official Full Name: heterogeneous nuclear ribonucleoprotein A/Bprovided by HGNC

Gene Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06537 HNRNPAB Knockout cell line (HeLa) Human HNRNPAB 1:3~1:6 Negative Online Inquiry
KO06538 HNRNPAB Knockout cell line (HCT 116) Human HNRNPAB 1:2~1:4 Negative Online Inquiry
KO06539 HNRNPAB Knockout cell line (HEK293) Human HNRNPAB 1:3~1:6 Negative Online Inquiry
KO06540 HNRNPAB Knockout cell line (A549) Human HNRNPAB 1:3~1:4 Negative Online Inquiry

Background

HNRNPAB Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the Heterogeneous Nuclear Ribonucleoprotein A/B (HNRNPAB) gene. HNRNPAB is a key player in the regulation of gene expression and pre-mRNA processing, influencing alternative splicing, RNA stability, and transport. By utilizing these knockout cell lines, researchers can investigate the functional roles of HNRNPAB in various biological processes, including cellular stress responses, differentiation, and disease mechanisms.

The primary mechanism of the HNRNPAB gene knockout involves CRISPR-Cas9 technology, which allows for precise editing of the genome, ensuring the complete ablation of HNRNPAB expression. This specificity enhances the robustness of experimental results, providing clear insights into the gene's contributions to cellular function. The cell lines offer a valuable platform for elucidating the complex interactions of HNRNPAB in RNA metabolism and signaling pathways, thus aiding in the identification of potential therapeutic targets for diseases such as cancer and neurodegenerative disorders.

From a scientific standpoint, these cell lines are invaluable for both basic and applied research. They enable in-depth studies of HNRNPAB's role in modulating gene expression, thereby assisting in the understanding of cellular processes that underpin various pathologies. They also present a systematic approach to evaluating the effects of drug candidates that may target RNA binding proteins.

What sets our HNRNPAB Gene Knockout Cell Lines apart from alternatives is the stringent validation of functionality and genomic integrity, providing researchers with reliable and consistent models. Additionally, these cell lines are readily accessible and can be easily integrated into existing experimental workflows, saving time and resources.

In summary, HNRNPAB Gene Knockout Cell Lines are a crucial tool for researchers and clinicians striving to understand the depths of RNA biology and its implications in human health. Our company prides itself on offering high-quality biological products backed by exceptional expertise, ensuring that our customers have the tools they need to drive their research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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