Gene: HNF4G
Official Full Name: hepatocyte nuclear factor 4 gammaprovided by HGNC
Gene Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37311 | HNF4G Knockout cell line (HCT 116) | Human | HNF4G | 1:2~1:4 | Negative | Online Inquiry |
KO37312 | HNF4G Knockout cell line (HEK293) | Human | HNF4G | 1:3~1:6 | Negative | Online Inquiry |
KO37313 | HNF4G Knockout cell line (A549) | Human | HNF4G | 1:3~1:4 | Negative | Online Inquiry |
HNF4G Gene Knockout Cell Lines are engineered cellular models that have had the Hepatocyte Nuclear Factor 4 Gamma (HNF4G) gene specifically disrupted, facilitating targeted studies of gene function, pathophysiology, and therapeutic intervention strategies. The knockout mechanism involves the use of CRISPR/Cas9 technology, which allows for precise editing of the genome, resulting in a cell line that can be utilized to investigate the role of HNF4G in various biological processes.
HNF4G is a critical transcription factor that regulates metabolic processes, thus its knockout provides insights into metabolic disorders, liver function, and even implications in cancer biology. By removing this gene's influence, researchers can elucidate pathways directly involved in fatty acid metabolism and glucose homeostasis, further contributing to understanding diseases such as non-alcoholic fatty liver disease (NAFLD) and diabetes. These cell lines serve not only as robust models for gene function studies but also offer pathways to assess new therapeutic targets aimed at diseases associated with HNF4G dysregulation.
What distinguishes our HNF4G Gene Knockout Cell Lines from other available genetic models is their superior specificity and reliability, coupled with high reproducibility in experimental conditions. Unlike traditional models, which may involve lengthy processes and ambiguous results, our cell lines permit rapid experimental setups and validation of hypotheses regarding HNF4G function with confidence. The ease of usage also aims to streamline workflows in both basic and applied research.
For researchers and clinicians, these cell lines represent invaluable tools for advancing the understanding of metabolic conditions, paving the way for innovative treatments. By utilizing our HNF4G Gene Knockout Cell Lines, you gain access to a cutting-edge resource that enhances the potential for breakthrough discoveries in genetic research and therapeutic development.
Furthermore, our company prides itself on a strong foundation built on extensive experience in biological product development and a commitment to providing high-quality research tools. With our expertise, we aim to empower the scientific community with reliable, state-of-the-art solutions that contribute to meaningful advancements in health and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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