Gene: HMGN4
Official Full Name: high mobility group nucleosomal binding domain 4provided by HGNC
Gene Summary: The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. [provided by RefSeq, Mar 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02413 | HMGN4 Knockout cell line (HeLa) | Human | HMGN4 | 1:3~1:6 | Negative | Online Inquiry |
KO02414 | HMGN4 Knockout cell line (HCT 116) | Human | HMGN4 | 1:2~1:4 | Negative | Online Inquiry |
KO02415 | HMGN4 Knockout cell line (HEK293) | Human | HMGN4 | 1:3~1:6 | Negative | Online Inquiry |
KO02416 | HMGN4 Knockout cell line (A549) | Human | HMGN4 | 1:3~1:4 | Negative | Online Inquiry |
HMGN4 Gene Knockout Cell Lines are precisely engineered cellular models designed for the study of the high-mobility group nucleosome-binding protein 4 (HMGN4). These cell lines are generated through advanced CRISPR-Cas9 gene editing technology, effectively removing expression of the HMGN4 gene, allowing researchers to assess its biological role in cellular processes. HMGN4 plays a critical role in chromatin remodeling and regulation of gene expression, making these knockout cell lines invaluable tools for identifying the pathways and mechanisms influenced by this protein.
The primary function of HMGN4 involves its binding affinity to nucleosomes, where it modulates chromatin structure, thus influencing gene accessibility and transcriptional activity. By utilizing HMGN4 Gene Knockout Cell Lines, researchers can investigate the consequences of HMGN4 disruption, enabling studies on gene regulation, oncogenesis, and developmental biology, as well as the cellular response to various stimuli.
From a scientific perspective, these knockout cell lines are crucial for elucidating the roles of HMGN4 in health and disease. They provide an experimental platform for drug discovery, enabling the evaluation of therapeutic compounds targeting pathways modulated by HMGN4. The unique advantage of utilizing these specific cell lines over wild-type variants lies in the ability to observe gene function without the confounding effects of HMGN4 expression, thus providing clearer insights into its role.
The affordability and reliability of our HMGN4 Gene Knockout Cell Lines, coupled with their capacity to yield reproducible results, make them an essential resource for researchers and clinicians alike. These cell lines not only enhance experimental efficiency but also facilitate significant advancements in the understanding of epigenetic regulations. Our company is committed to delivering high-quality biological products, backed by extensive expertise in gene editing technologies and cellular biology, ensuring that researchers have the best tools at their disposal for innovative discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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