Gene: HLF
Official Full Name: HLF transcription factor, PAR bZIP family memberprovided by HGNC
Gene Summary: This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05897 | HLF Knockout cell line (HCT 116) | Human | HLF | 1:2~1:4 | Negative | Online Inquiry |
KO05898 | HLF Knockout cell line (HEK293) | Human | HLF | 1:3~1:6 | Negative | Online Inquiry |
HLF Gene Knockout Cell Lines are genetically engineered cell lines that have had the HLF gene (Hepatic Leucine-rich alpha-2-glycoprotein) completely disabled or "knocked out." These cell lines facilitate in-depth studies of gene function, cellular pathways, and disease mechanisms by providing a controlled environment to assess the phenotypic consequences of HLF gene deletion. The primary mechanism underlying these cell lines utilizes advanced genome editing technologies, such as CRISPR/Cas9, to ensure precise targeting and disruption of the HLF gene.
The scientific importance of HLF Gene Knockout Cell Lines cannot be overstated, as they serve as critical tools in various research fields, including cancer biology, metabolic disorders, and regenerative medicine. Their application extends to fundamentally understanding the role of the HLF gene in liver function and pathologies, thereby aiding in the identification of novel therapeutic targets and biomarkers. Clinically, these cell lines enable researchers to perform high-throughput screening of drug compounds that might restore normal cellular functions or mitigate pathological conditions associated with HLF dysregulation.
One of the standout advantages of HLF Gene Knockout Cell Lines is their specificity and reproducibility in experiments, which improves the reliability of research findings. Compared to existing alternatives, these engineered cell lines minimize off-target effects and provide a more accurate representation of gene knockout scenarios. Additionally, they come with extensive documentation of their validation and characterization, ensuring that researchers can trust the results obtained from using them.
For researchers and clinicians seeking to unravel the complexities of gene function and develop innovative therapeutic strategies, HLF Gene Knockout Cell Lines offer an invaluable resource that bridges laboratory discoveries with clinical applications. Our company stands at the forefront of genetic research tools, leveraging years of expertise in cell line engineering to provide high-quality biological products that drive scientific advancement and improve health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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