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HKDC1 Knockout Cell Lines

Gene: HKDC1

Official Full Name: hexokinase domain containing 1provided by HGNC

Gene Summary: This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08260 HKDC1 Knockout cell line (HCT 116) Human HKDC1 1:2~1:4 Negative Online Inquiry
KO08261 HKDC1 Knockout cell line (A549) Human HKDC1 1:3~1:4 Negative Online Inquiry

Background

HKDC1 Gene Knockout Cell Lines are a cutting-edge biological tool designed to facilitate the study of the HKDC1 gene’s role in cellular processes, particularly in the context of hepatic glucose metabolism and insulin signaling pathways. By employing advanced CRISPR-Cas9 gene-editing technology, these cell lines have been meticulously engineered to render the HKDC1 gene inactive, enabling researchers to investigate the downstream effects of this gene's disruption on cell function and metabolic regulation.

The primary function of the HKDC1 Gene Knockout Cell Lines is to provide a controlled environment in which the implications of HKDC1 loss can be elucidated. By analyzing metabolic changes in these knockout models, researchers can explore how HKDC1 influences key physiological processes including glycolysis and gluconeogenesis, thereby contributing to a deeper understanding of metabolic disorders such as type 2 diabetes and non-alcoholic fatty liver disease. This model is particularly valuable for examining gene interactions and potential therapeutic targets.

The scientific importance of these cell lines cannot be overstated; they serve as an essential tool for basic research and drug development. Their applications extend to metabolic research, drug screening, and biomarker discovery, making them indispensable in both academic and clinical settings.

What sets HKDC1 Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility. Traditional models often rely on pharmacological inhibitors or antisense oligonucleotides that might produce off-target effects or incomplete gene suppression. In contrast, the complete elimination of HKDC1 allows for more precise experimental outcomes, leading to more reliable data.

For researchers and clinicians, the value of HKDC1 Gene Knockout Cell Lines lies in their ability to offer robust, actionable insights into the genetic underpinnings of metabolic diseases. By utilizing these cell lines, users can accelerate their research timelines and enhance the quality of their findings.

At our company, we are committed to providing state-of-the-art biological products backed by rigorous scientific validation. Our expertise in gene editing technologies ensures that researchers can rely on our products for their innovative scientific inquiries and therapeutic developments.

Please note that all services are for research use only. Not intended for any clinical use.

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