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HIP1 Knockout Cell Lines

Gene: HIP1

Official Full Name: huntingtin interacting protein 1provided by HGNC

Gene Summary: The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37384 HIP1 Knockout cell line (HeLa) Human HIP1 1:3~1:6 Negative Online Inquiry
KO37385 HIP1 Knockout cell line (HCT 116) Human HIP1 1:2~1:4 Negative Online Inquiry
KO37386 HIP1 Knockout cell line (HEK293) Human HIP1 1:3~1:6 Negative Online Inquiry
KO37387 HIP1 Knockout cell line (A549) Human HIP1 1:3~1:4 Negative Online Inquiry

Background

HIP1 Gene Knockout Cell Lines represent a groundbreaking advancement in the realm of genetic research and functional studies. These cell lines have been meticulously engineered to exhibit a complete deficiency of the huntingtin interacting protein 1 (HIP1), a critical player in various cellular processes, including vesicle trafficking and gene expression regulation. By creating a knockout model, researchers can effectively assess the role of HIP1 in cellular pathways and disease mechanisms, offering profound insights into its implications in neurodegenerative disorders and cancer.

The primary function of HIP1 Gene Knockout Cell Lines lies in their ability to elucidate the biological consequences of HIP1 absence. By utilizing CRISPR/Cas9 and other gene-editing technologies, these cell lines allow for precise control over the genetic landscape, facilitating the study of gene function and the examination of phenotypic differences compared to wild-type cells. Understanding the mechanisms by which HIP1 influences critical cellular functions paves the way for developing targeted therapeutics and innovative treatments.

The scientific importance of HIP1 Gene Knockout Cell Lines is underscored by their utility in both basic and translational research settings. They serve as valuable tools for investigating the mechanistic basis of various diseases, including Huntington's disease and certain forms of cancer where HIP1 dysregulation has been implicated. Such applications promise to enhance our understanding of disease pathology and inform the development of novel pharmacological interventions.

What sets HIP1 Gene Knockout Cell Lines apart from alternative models is their reliability, specificity, and versatility. Many existing models may exhibit off-target effects or incomplete knockout efficiencies, impacting experimental outcomes. In contrast, our expertly validated cell lines guarantee a robust and reproducible platform for precise scientific exploration, streamlining your research process.

For researchers and clinicians alike, the value of HIP1 Gene Knockout Cell Lines cannot be overstated. Their use will not only advance the field of molecular biology but will also contribute to the overarching goal of advancing human health through innovative research pathways. With years of experience in biotechnological advancements and a commitment to excellence, our company is dedicated to providing high-quality, reliable research tools to empower the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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