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HEYL Knockout Cell Lines

Gene: HEYL

Official Full Name: hes related family bHLH transcription factor with YRPW motif likeprovided by HGNC

Gene Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11394 HEYL Knockout cell line (HCT 116) Human HEYL 1:2~1:4 Negative Online Inquiry
KO11395 HEYL Knockout cell line (HEK293) Human HEYL 1:3~1:6 Negative Online Inquiry
KO11396 HEYL Knockout cell line (A549) Human HEYL 1:3~1:4 Negative Online Inquiry

Background

HEYL Gene Knockout Cell Lines are a transformative tool in molecular biology, engineered to facilitate the study of gene function and regulation. These cell lines are created through CRISPR/Cas9 technology, resulting in precise deletions of the HEYL gene, a crucial regulator involved in cellular signaling and developmental processes. By completely knocking out the expression of this gene, researchers can elucidate its role in various biological contexts and diseases.

The primary function of HEYL Gene Knockout Cell Lines lies in their ability to model gene loss-of-function scenarios. This allows scientists to investigate how the absence of HEYL influences cellular behaviors such as differentiation, proliferation, and response to environmental stimuli. The knockout mechanism relies on the effectiveness of the CRISPR/Cas9 system, which introduces double-strand breaks in the DNA, prompting the cell’s repair machinery to disable the HEYL gene, thereby providing a clean slate for functional studies.

In both research and clinical settings, these cell lines are indispensable for understanding the pathology of diseases where HEYL is implicated, such as certain cancers and developmental disorders. They enable high-throughput screening for drug candidates targeting HEYL-related pathways, thus opening avenues for therapeutic intervention.

The advantages of HEYL Gene Knockout Cell Lines include their robustness and reproducibility, ensuring consistent experimental outcomes. Compared to alternative models that might rely on transient expression systems or less precise gene editing techniques, our knockout lines provide more stable and long-lasting phenotypic changes for in-depth analysis.

For researchers and clinicians focused on gene regulation and disease mechanisms, HEYL Gene Knockout Cell Lines present valuable insights that can drive innovation in therapeutic strategies. By leveraging cutting-edge genetic engineering techniques, our product contributes to advancements in the life sciences field, empowering users with reliable models that enhance experimental rigor.

Our company prides itself on its advanced expertise in genetic engineering, delivering high-quality biological products that support the scientific community's pursuit of discovery and improvement in human health.

Please note that all services are for research use only. Not intended for any clinical use.

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