Gene: HESX1
Official Full Name: HESX homeobox 1provided by HGNC
Gene Summary: This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03674 | HESX1 Knockout cell line (HeLa) | Human | HESX1 | 1:3~1:6 | Negative | Online Inquiry |
KO03675 | HESX1 Knockout cell line (HCT 116) | Human | HESX1 | 1:2~1:4 | Negative | Online Inquiry |
KO03676 | HESX1 Knockout cell line (HEK293) | Human | HESX1 | 1:3~1:6 | Negative | Online Inquiry |
KO03677 | HESX1 Knockout cell line (A549) | Human | HESX1 | 1:3~1:4 | Negative | Online Inquiry |
HESX1 Gene Knockout Cell Lines are specialized cellular models designed to study the function of the HESX1 gene, which plays an integral role in neural development and pituitary gland formation. By employing CRISPR-Cas9 technology to induce a targeted knockout of the HESX1 gene, these cell lines provide a unique opportunity to explore the biological effects and downstream signaling pathways influenced by HESX1 deficiency.
The primary mechanism of these cell lines involves the interruption of HESX1 transcription, allowing researchers to analyze the resultant phenotypic changes, gene expression profiles, and cellular behavior compared to wild-type counterparts. This knockout approach is invaluable for dissecting the gene's role in development, disease models, and gene regulation. By inhibiting the expression of HESX1, researchers can better understand its contributions to conditions such as combined pituitary hormone deficiency, which underscores the clinical relevance of this product.
One of the key advantages of HESX1 Gene Knockout Cell Lines is their precision and reliability, achieved through cutting-edge gene-editing techniques that ensure thorough and consistent gene disruption. This provides researchers with reproducible and more physiologically relevant models than conventional methods, such as RNA interference or pharmacological inhibitors, which may lack specificity or introduce off-target effects.
For researchers and clinicians focused on developmental biology, endocrinology, or genetic disorders, HESX1 Gene Knockout Cell Lines represent a vital tool in unraveling complex cellular mechanisms. They open pathways for innovative therapeutic strategies and biomarker discovery, highlighting their immense potential in advancing scientific knowledge and clinical applications.
With a strong commitment to precision and quality, our company brings extensive expertise in gene editing and cell line development, ensuring that our products meet the highest standards for your research needs. By choosing HESX1 Gene Knockout Cell Lines, you are selecting a reliable resource that can propel your studies to new heights.
Please note that all services are for research use only. Not intended for any clinical use.
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