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HERC6 Knockout Cell Lines

Gene: HERC6

Official Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 6provided by HGNC

Gene Summary: HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17134 HERC6 Knockout cell line (HeLa) Human HERC6 1:3~1:6 Negative Online Inquiry
KO17135 HERC6 Knockout cell line (HCT 116) Human HERC6 1:2~1:4 Negative Online Inquiry
KO17136 HERC6 Knockout cell line (HEK293) Human HERC6 1:3~1:6 Negative Online Inquiry
KO17137 HERC6 Knockout cell line (A549) Human HERC6 1:3~1:4 Negative Online Inquiry

Background

HERC6 Gene Knockout Cell Lines are specialized cellular models designed for advanced genetic research and therapeutic development. These cell lines have undergone precise genetic modifications to achieve the knockout of the HERC6 gene, a member of the HERC family that plays a pivotal role in ubiquitination and protein degradation pathways. By disrupting the function of HERC6, researchers can investigate its critical involvement in cellular processes such as DNA repair, cell cycle regulation, and response to stressors.

The primary function of HERC6 Gene Knockout Cell Lines lies in their ability to elucidate the biological consequences of HERC6 deficiency. This includes studying alterations in signal transduction pathways, the impact on ubiquitin-proteasome systems, and how these changes influence tumorigenesis and other disease states. The generated cell lines serve as invaluable tools for exploring the fundamental biological questions surrounding gene function and the molecular mechanisms underlying various disorders, including cancer and neurodegenerative diseases.

In a research setting, these cell lines provide a controlled platform for drug screening, biomarker discovery, and validation of therapeutic targets. The unique advantage of HERC6 Gene Knockout Cell Lines over traditional cell lines is their explicit genetic modification, allowing for a clearer interpretation of results directly linked to the absence of the HERC6 gene. This specificity enhances the reproducibility of experimental outcomes and yields more reliable insights, making it easier for researchers to establish causal relationships in their investigations.

Moreover, these cell lines offer researchers the potential to design and test novel therapeutic strategies, contributing to the broader landscape of precision medicine. In clinical realms, these knockout models can assist in the identification of biomarkers for personalized therapies, ultimately advancing patient outcomes.

[Your Company's Name] is committed to providing innovative biological products that empower the scientific community. With a focus on quality and precision, our HERC6 Gene Knockout Cell Lines are meticulously developed to support your research, unlocking new avenues for discovery in the quest to understand and combat complex diseases.

Please note that all services are for research use only. Not intended for any clinical use.

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