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HERC2 Knockout Cell Lines

Gene: HERC2

Official Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2provided by HGNC

Gene Summary: This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05849 HERC2 Knockout cell line (HeLa) Human HERC2 1:3~1:6 Negative Online Inquiry
KO05850 HERC2 Knockout cell line (HCT 116) Human HERC2 1:2~1:4 Negative Online Inquiry
KO05851 HERC2 Knockout cell line (HEK293) Human HERC2 1:3~1:6 Negative Online Inquiry
KO05852 HERC2 Knockout cell line (A549) Human HERC2 1:3~1:4 Negative Online Inquiry

Background

HERC2 Gene Knockout Cell Lines represent a cutting-edge biological tool designed for in-depth genetic research and functional studies. These engineered cell lines have been meticulously developed to silence or completely disrupt the HERC2 gene, allowing researchers to investigate the gene's specific roles and interactions in various biological processes, such as cell proliferation, differentiation, and response to environmental stimuli.

The core function of these knockout cell lines involves the strategic deletion of the HERC2 gene, which encodes a key E3 ubiquitin ligase involved in various cellular mechanisms, including DNA repair. This gene’s absence facilitates the elucidation of its contributions to disorders and complex physiological responses, making it invaluable for research into diseases such as cancer and neurodegeneration. By providing a clean genetic background, these cell lines enable precise studies that minimize confounding genetic variables that can obscure results when using wild-type cells.

In the realm of scientific importance, HERC2 Gene Knockout Cell Lines serve as essential models for drug discovery and the evaluation of therapeutic efficacy. They support advanced research on protein interactions and cellular pathways, potentially leading to novel insights in therapeutics and personalized medicine.

One of the key advantages of using HERC2 Gene Knockout Cell Lines is their reproducibility and reliability. Unlike traditional methods of gene editing that may introduce off-target effects or vary in efficiency, our knockout cell lines offer consistent gene disruption verified through rigorous validation processes. This enhances research integrity and allows researchers to trust the data obtained from these models.

For researchers and clinicians aiming to delve into the intricacies of genetic functions and disease mechanisms, these cell lines provide a robust platform that accelerates discovery and innovation. Our commitment to excellence in producing high-quality biological products and leveraging advanced gene editing technologies ensures that talented researchers and healthcare professionals have access to the finest tools needed to advance their work.

With our extensive expertise in genetic engineering and a portfolio of biologically relevant products, we empower scientists and clinicians alike to push the boundaries of science and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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