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HECTD2 Knockout Cell Lines

Gene: HECTD2

Official Full Name: HECT domain E3 ubiquitin protein ligase 2provided by HGNC

Gene Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24284 HECTD2 Knockout cell line (HeLa) Human HECTD2 1:3~1:6 Negative Online Inquiry
KO24285 HECTD2 Knockout cell line (HCT 116) Human HECTD2 1:2~1:4 Negative Online Inquiry
KO24286 HECTD2 Knockout cell line (HEK293) Human HECTD2 1:3~1:6 Negative Online Inquiry
KO24287 HECTD2 Knockout cell line (A549) Human HECTD2 1:3~1:4 Negative Online Inquiry

Background

HECTD2 Gene Knockout Cell Lines are genetically modified cellular models designed to specifically disable the HECTD2 gene, which encodes a HECT-type E3 ubiquitin ligase that plays a critical role in various cellular processes, including protein degradation, cell division, and signal transduction. By utilizing CRISPR/Cas9 technology or other gene-editing techniques, these cell lines provide a powerful tool for researchers to study the functional implications of HECTD2 loss in both normal and pathological states.

The key mechanism of action lies in the targeted disruption of the HECTD2 gene, which leads to altered ubiquitination and subsequent changes in the protein homeostasis of the cell. This knockout model enables researchers to dissect the biological pathways influenced by HECTD2, providing insights into its involvement in oncogenesis, neurodegenerative diseases, and cell cycle regulation. The ability to observe these changes in vitro equips scientists with valuable data that can lead to the development of novel therapeutic strategies.

HECTD2 Gene Knockout Cell Lines hold significant scientific importance in fundamental research as well as translational applications. They serve as robust models for drug screening, biomarker discovery, and the validation of therapeutic targets. Such applications are invaluable in advancing our understanding of diseases where HECTD2 is implicated and offer potential pathways for tailored medical interventions.

Compared to unmodified cell lines or alternative models, HECTD2 Gene Knockout Cell Lines provide researchers with a precise alteration at the genomic level, ensuring reproducibility and higher biological relevance. Furthermore, these models allow for easier comparison with wild-type cells under controlled experimental conditions, facilitating a more nuanced understanding of cellular dynamics.

For researchers and clinicians striving to push the boundaries of biological inquiry or develop new treatments, HECTD2 Gene Knockout Cell Lines represent a unique offering that empowers exploration into the intricate interplay of cellular mechanisms. Our company prides itself on its expertise in genetic engineering and commitment to providing top-tier biological products, ensuring that researchers have the best tools available to further their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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