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HDAC6 Knockout Cell Lines

Gene: HDAC6

Official Full Name: histone deacetylase 6provided by HGNC

Gene Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00513 HDAC6 knockout cell line (HEK293) Human HDAC6 1:3~1:6 Negative Online Inquiry
KO05963 HDAC6 Knockout cell line (HeLa) Human HDAC6 1:3~1:6 Negative Online Inquiry
KO05964 HDAC6 Knockout cell line (HCT 116) Human HDAC6 1:2~1:4 Negative Online Inquiry
KO05965 HDAC6 Knockout cell line (A549) Human HDAC6 1:3~1:4 Negative Online Inquiry

Background

HDAC6 Gene Knockout Cell Lines are genetically modified cell lines that have undergone specific gene-editing techniques to knock out the HDAC6 gene, which encodes for a histone deacetylase enzyme predominantly involved in cellular processes such as protein degradation, cytoskeleton organization, and stress response. These cell lines facilitate the study of the functional roles of HDAC6 in various biological contexts, enabling scientists to explore its contributions to neuronal function, cancer progression, and autoimmune diseases.

The primary function of the HDAC6 enzyme involves the deacetylation of non-histone proteins, impacting the regulation of cellular signaling pathways and transcriptional control. By knocking out HDAC6, researchers can investigate the consequences of its absence on cellular behavior, including alterations in gene expression patterns, cell proliferation, and apoptosis. This understanding can unravel the pathological mechanisms of diseases where HDAC6 is implicated, opening avenues for therapeutic development.

In research and clinical settings, HDAC6 Gene Knockout Cell Lines have significant implications, particularly in the fields of oncology and neurobiology. They serve as powerful tools for drug discovery and testing, allowing for the evaluation of new compounds targeting HDAC6-related pathways. Moreover, these cell lines can contribute to biomarker identification, screening assays, and mechanistic studies that advance the understanding of complex diseases.

Compared to traditional models, HDAC6 Gene Knockout Cell Lines offer distinct advantages, including higher specificity and reproducibility. Their use over less precise knockout methods enhances the reliability of experimental results and accelerates the pace of research. Additionally, these cell lines are designed for ease of use, with optimized culture conditions and characterization profiles that ensure consistency in experimental outcomes.

Ultimately, the value of HDAC6 Gene Knockout Cell Lines to researchers and clinicians is substantial, as they bridge the gap between basic research and clinical application, fostering the development of targeted therapies. Our company specializes in providing high-quality, validated biological products tailored for advanced research needs. With extensive expertise in gene editing and cell line development, we are committed to supporting scientists in their quest for innovative treatment strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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