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HAP1 Knockout Cell Lines

Gene: HAP1

Official Full Name: huntingtin associated protein 1provided by HGNC

Gene Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33665 HAP1 Knockout cell line (HCT 116) Human HAP1 1:2~1:4 Negative Online Inquiry
KO33666 HAP1 Knockout cell line (HEK293) Human HAP1 1:3~1:6 Negative Online Inquiry
KO33667 HAP1 Knockout cell line (A549) Human HAP1 1:3~1:4 Negative Online Inquiry

Background

HAP1 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the HAP1 gene, a crucial component in various cellular processes, including neuronal signaling and intracellular transport. These cell lines serve as powerful tools for researchers looking to understand the biological role of the HAP1 protein and its implications in health and disease, particularly in neurodegenerative disorders.

The primary function of HAP1 is to facilitate the trafficking of proteins and signaling molecules within neurons. By utilizing HAP1 Gene Knockout Cell Lines, researchers can investigate the downstream effects of HAP1 loss, either through gene expression analysis or by examining changes in cellular behavior. The knockout model effectively mimics conditions found in specific neurological diseases, allowing for the dissection of molecular pathways and identification of potential therapeutic targets.

From a scientific standpoint, HAP1 Gene Knockout Cell Lines are invaluable in both basic research and clinical applications. They provide insights into disease mechanisms that could lead to novel treatment strategies, especially for conditions like Huntington's disease and other neurodegenerative disorders. Their relevance in drug screening and validation makes them an asset in the pharmaceutical industry as well.

One significant advantage of HAP1 Gene Knockout Cell Lines is their robustness and reliability compared to traditional siRNA knockdown methods, which can often result in incomplete gene suppression. These knockout lines offer a stable, long-term solution for continuous studies, enabling reproducible results across multiple experiments. Additionally, they alleviate the variability associated with transient transfection techniques, ensuring that findings are attributable solely to the genetic alteration.

For researchers and clinicians focused on neurobiology and therapeutic development, HAP1 Gene Knockout Cell Lines present a unique opportunity to advance understanding and treatment of complex diseases. Their ability to serve as consistent models underscores their potential to facilitate breakthrough discoveries. Our company specializes in manufacturing high-quality biological research products, ensuring that each cell line is extensively validated and supported by comprehensive technical documentation to assist users in achieving their research goals effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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