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H6PD Knockout Cell Lines

Gene: H6PD

Official Full Name: hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenaseprovided by HGNC

Gene Summary: There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33096 H6PD Knockout cell line (HeLa) Human H6PD 1:3~1:6 Negative Online Inquiry
KO33097 H6PD Knockout cell line (HCT 116) Human H6PD 1:2~1:4 Negative Online Inquiry
KO33098 H6PD Knockout cell line (HEK293) Human H6PD 1:3~1:6 Negative Online Inquiry
KO33099 H6PD Knockout cell line (A549) Human H6PD 1:3~1:4 Negative Online Inquiry

Background

H6PD Gene Knockout Cell Lines represent a vital tool in genetic research, created via sophisticated gene editing techniques to disable the H6PD gene, which encodes the enzyme hexose-6-phosphate dehydrogenase. This enzyme is critical in the pentose phosphate pathway, playing a significant role in cellular metabolism and the production of NADPH, a cofactor essential for various biosynthetic reactions and antioxidant defense mechanisms. By studying H6PD gene knockout models, researchers can gain insights into the metabolic alterations associated with oxidative stress and their implications in diseases such as diabetes, cancer, and neurodegenerative disorders.

The primary function of H6PD Gene Knockout Cell Lines lies in their ability to elucidate the physiological and pathological roles of H6PD. The absence of this enzyme allows for the investigation of downstream effects on metabolic pathways, oxidative stress responses, and cellular signaling. By observing these alterations, researchers can develop better therapeutic strategies and understand the enzyme's contributions to disease mechanisms.

In research and clinical settings, these cell lines provide a robust platform for drug screening, target validation, and understanding disease progression, contributing significantly to translational medicine. The H6PD knockout model enables scientists to explore metabolic diseases at the cellular level, offering insights that can lead to the development of novel therapies.

What sets our H6PD Gene Knockout Cell Lines apart from competitors is our commitment to authenticity and quality. Our cell lines undergo rigorous characterization and validation to ensure reproducibility and reliability in experiments. Additionally, we offer comprehensive support, including detailed protocols and troubleshooting assistance, empowering researchers to achieve optimal results in their studies.

In summary, H6PD Gene Knockout Cell Lines are invaluable for those aiming to advance our understanding of metabolic disorders and oxidative stress-related diseases. Our company's expertise in providing high-quality biological products ensures that you have access to the most effective tools for your research and clinical applications, enabling the advancement of groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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