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H2BW2 Knockout Cell Lines

Gene: H2BW2

Official Full Name: H2B.W histone 2provided by HGNC

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family. [provided by RefSeq, Nov 2015]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17188 H2BW2 Knockout cell line (HEK293) Human H2BW2 1:3~1:6 Negative Online Inquiry

Background

H2BW2 Gene Knockout Cell Lines are sophisticated biological tools specifically engineered for the targeted disruption of gene expression. Utilizing advanced CRISPR-Cas9 technology, these cell lines enable precise modifications at the genomic level, facilitating the study of gene function and the role of specific proteins in cellular processes. By knocking out particular genes, researchers can gain insights into cellular pathways, disease mechanisms, and therapeutic targets, making these cell lines invaluable in experimental and clinical research settings.

The primary function of H2BW2 Gene Knockout Cell Lines revolves around their ability to generate a loss-of-function phenotype for selected genes. The CRISPR-Cas9 system uses RNA-guided endonucleases to induce double-strand breaks in specific genomic locations, followed by cellular repair mechanisms that often result in gene knockout through insertion/deletion mutations. This targeted gene alteration allows for the examination of gene-related roles in various biological processes, including cancer development, metabolic regulation, and immunological responses.

From a scientific standpoint, the H2BW2 Gene Knockout Cell Lines hold significant importance in advancing research in genetic disorders, drug development, and synthetic biology. Their application spans fundamental research, therapeutic discovery, and translational studies, enabling researchers and clinicians to explore new avenues of treatment and diagnosis.

What sets H2BW2 apart from other gene knockout systems is its high efficiency and specificity, allowing for minimal off-target effects. Unlike traditional gene silencing techniques, which may lead to incomplete gene disruption, H2BW2 ensures robust and complete knockout, ultimately leading to more reliable experimental outcomes. The versatility of these cell lines also means they can be adapted for various platforms, including 2D and 3D cell cultures.

For researchers and clinicians aiming to enhance their understanding of gene function and its implications in health and disease, H2BW2 Gene Knockout Cell Lines provide a powerful and efficient toolset. Their potential for catalyzing important findings in the scientific community cannot be overstated. Backed by our company’s expertise in genetic engineering and commitment to quality, we offer a comprehensive range of biologically relevant products that empower research and innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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