Home / H2AJ Knockout Cell Lines

H2AJ Knockout Cell Lines

Gene: H2AJ

Official Full Name: H2A.J histoneprovided by HGNC

Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17202 H2AJ Knockout cell line (HeLa) Human H2AJ 1:3~1:6 Negative Online Inquiry
KO17203 H2AJ Knockout cell line (HCT 116) Human H2AJ 1:2~1:4 Negative Online Inquiry
KO17204 H2AJ Knockout cell line (HEK293) Human H2AJ 1:3~1:6 Negative Online Inquiry
KO17205 H2AJ Knockout cell line (A549) Human H2AJ 1:3~1:4 Negative Online Inquiry

Background

H2AJ Gene Knockout Cell Lines are a state-of-the-art biological tool designed to facilitate advanced genetic research by enabling the targeted ablation of specific genes. These cell lines are engineered using CRISPR/Cas9 technology, a revolutionary genome-editing platform that allows for precise modifications in the DNA sequence. By knocking out the H2AJ gene, researchers can study its function and role in various cellular processes, including development, gene regulation, and cellular response to stress.

The key mechanism of H2AJ Gene Knockout Cell Lines is based on the efficient induction of double-strand breaks in the genome, followed by the cell's natural repair processes which can lead to the complete loss of gene function. This targeted approach provides researchers with the ability to create models that closely mimic genetic disorders or the effects of specific gene deletions, thereby enhancing experimental validity. By understanding the biological pathways involved, scientists can delve deeper into disease mechanisms, paving the way for novel therapeutic strategies.

Scientific significance is paramount as these knockout cell lines serve as valuable models in both basic research and clinical applications. They are instrumental in cancer research, drug discovery, and the functional validation of potential therapeutic targets. With the increasing prevalence of gene therapies and personalized medicine, tools like the H2AJ Gene Knockout Cell Lines offer unprecedented opportunities to deconvolute complex biological systems.

What sets H2AJ Gene Knockout Cell Lines apart from traditional cell lines is their unparalleled accuracy and specificity in gene targeting, combined with the speed and ease of use afforded by CRISPR technology. Researchers can generate and utilize these knockout models with greater confidence than ever before, significantly reducing experimental variability and enhancing reproducibility.

Ultimately, H2AJ Gene Knockout Cell Lines represent a substantial investment in the future of molecular biology and genetic research. Their practicality and scientific robustness make them an invaluable resource for academic labs and biotechnology companies alike. Our company is committed to providing high-quality, reliable biological products, supported by robust expertise and ongoing innovation in genetic engineering, ensuring that researchers have the best tools at their disposal to advance their work and discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.