Gene: GYG2
Official Full Name: glycogenin 2provided by HGNC
Gene Summary: This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33749 | GYG2 Knockout cell line (HEK293) | Human | GYG2 | 1:3~1:6 | Negative | Online Inquiry |
KO33750 | GYG2 Knockout cell line (A549) | Human | GYG2 | 1:3~1:4 | Negative | Online Inquiry |
GYG2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to disrupt the expression of the glycogen synthase kinase-2 (GYG2) gene. This product serves as a critical tool for researchers investigating the role of GYG2 in cellular metabolism, glycogen storage, and various disease processes involving metabolic dysregulation. By utilizing a CRISPR/Cas9-based gene editing approach, these cell lines exhibit a complete knockout of the GYG2 gene, facilitating the study of gene function and elucidating pathways impacted by its absence.
The primary function of GYG2 knockout cell lines lies in their ability to provide insights into how GYG2 contributes to glycogen metabolism. In these lines, researchers can observe the physiological effects of GYG2 deficiency on cellular processes, such as energy production, signaling pathways, and stress responses. This understanding is crucial for the development of therapeutic strategies targeting metabolic disorders, diabetes, and related conditions where GYG2 activity may be aberrant.
The scientific importance of GYG2 knockout cell lines extends to various fields, including biochemistry, molecular biology, and pharmacological research. These cell lines are instrumental for drug discovery efforts that seek to modulate glycogen metabolism, as they enable high-throughput screening for compounds that may restore balance to metabolic processes. Furthermore, these tools are valuable in preclinical models assessing the potential adverse effects of therapies that manipulate GYG2-related pathways.
Compared to alternative methods such as transient transfection or random mutagenesis, GYG2 knockout cell lines provide a stable and consistent model for long-term studies, allowing for reproducibility of results and minimizing variability. Researchers benefit from using these cell lines to achieve precise gene editing outcomes that enhance the reliability of experimental data.
For researchers and clinicians engaged in metabolic disease research, the GYG2 Gene Knockout Cell Lines represent an invaluable asset for dissecting enzymatic functions and exploring therapeutic avenues. With a focus on delivering robust research tools, our company is committed to advancing scientific understanding and medical innovation through high-quality biological products that support the expansive needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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