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GUCD1 Knockout Cell Lines

Gene: GUCD1

Official Full Name: guanylyl cyclase domain containing 1provided by HGNC

Gene Summary: Predicted to be involved in liver regeneration and response to cAMP. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25442 GUCD1 Knockout cell line (HeLa) Human GUCD1 1:3~1:6 Negative Online Inquiry
KO25443 GUCD1 Knockout cell line (HCT 116) Human GUCD1 1:2~1:4 Negative Online Inquiry
KO25444 GUCD1 Knockout cell line (HEK293) Human GUCD1 1:3~1:6 Negative Online Inquiry
KO25445 GUCD1 Knockout cell line (A549) Human GUCD1 1:3~1:4 Negative Online Inquiry

Background

GUCD1 Gene Knockout Cell Lines represent a powerful tool for scientists studying the biological functions of the GUCD1 gene, known for its role in glycosylation processes within mammalian cells. These engineered cell lines have undergone a precise genetic alteration that renders the GUCD1 gene inactive, providing a unique model to investigate the gene's contributions to cellular physiology and pathology.

The key mechanism behind the GUCD1 Gene Knockout Cell Lines lies in the application of advanced CRISPR/Cas9 gene-editing technology, which allows for specific and targeted disruption of the GUCD1 locus. By creating these knockout cell lines, researchers can obtain critical insights into how the absence of GUCD1 affects glycosylation patterns, protein maturation, and overall cellular function. Importantly, this knowledge can extend to understanding wider implications in diseases where glycosylation is compromised, such as congenital disorders of glycosylation (CDGs) and certain types of cancer.

The scientific importance of these cell lines is underscored by their applicability in both research and clinical settings. Researchers can utilize GUCD1 knockout models to explore therapeutic targets, develop drug screening assays, and further elucidate the pathways that depend on proper glycosylation. In clinical frameworks, these models can serve as platforms for understanding the mechanisms behind diseases associated with glycosylation abnormalities, paving the way for innovative treatment strategies.

One of the distinctive advantages of GUCD1 Gene Knockout Cell Lines over alternative models is their specificity and reliability. Unlike traditional methods that may provide ambiguous data, these cell lines offer a well-characterized, reproducible platform that enables more straightforward hypothesis testing. Furthermore, they are compatible with a variety of downstream applications, including gene expression analysis, metabolomics, and proteomics, bolstering their versatility in diverse research endeavors.

Researchers and clinicians value GUCD1 Gene Knockout Cell Lines for their potential to deliver groundbreaking insights into glycosylation-related mechanisms and disease states, making them an indispensable addition to the molecular biology toolkit. Our company prides itself on its expertise in gene editing technologies and biological product development, ensuring that each product, including GUCD1 knockout cell lines, meets the highest standards of quality and efficacy to support the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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