Gene: GUCA1B
Official Full Name: guanylate cyclase activator 1Bprovided by HGNC
Gene Summary: The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37456 | GUCA1B Knockout cell line (HCT 116) | Human | GUCA1B | 1:2~1:4 | Negative | Online Inquiry |
GUCA1B Gene Knockout Cell Lines are a specialized biological product designed to facilitate the exploration of the GUCA1B gene's function and its role in various physiological and pathological processes. The GUCA1B gene encodes a protein that is critical for signal transduction in retinal cells, and its knockout can provide valuable insights into its contributions to retinal diseases, such as retinitis pigmentosa and cone-rod dystrophy.
These knockout cell lines utilize CRISPR-Cas9 technology to create specific, targeted disruptions in the GUCA1B gene, effectively silencing its expression. This precise mechanism allows researchers to assess the resulting phenotypic changes in vitro, shedding light on how the absence of GUCA1B impacts cellular behavior, signaling pathways, and overall cell viability. By studying these alterations, researchers can elucidate the gene's role in the retinal phototransduction cascade and understand the underlying mechanisms of associated disorders.
The scientific importance of GUCA1B Gene Knockout Cell Lines is underscored by their applications in both basic research and clinical settings. They serve as a vital tool for investigating the molecular underpinnings of retinal diseases, thus supporting the development of novel therapeutic strategies and targeted gene therapies. Additionally, these cell lines are essential for drug screening and validation processes, making them invaluable for translational research that seeks to bridge laboratory findings with clinical applications.
What sets our GUCA1B Gene Knockout Cell Lines apart from alternatives is their unparalleled specificity and reliability. Each cell line is rigorously validated to ensure complete knockout of the target gene, thereby eliminating off-target effects or unintended mutations. This high degree of precision assures researchers of reproducibility in their experiments, a critical aspect of any experimental study.
Overall, GUCA1B Gene Knockout Cell Lines represent a breakthrough in researching retinal gene functions, providing researchers and clinicians the tools necessary for advancing knowledge and therapy development in vision science. With our company’s commitment to quality and innovation in biological products, we supply tools that are backed by extensive expertise and a dedication to supporting cutting-edge research.
Please note that all services are for research use only. Not intended for any clinical use.
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