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GSTP1 Knockout Cell Lines

Gene: GSTP1

Official Full Name: glutathione S-transferase pi 1provided by HGNC

Gene Summary: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09486 GSTP1 Knockout cell line (HeLa) Human GSTP1 1:3~1:6 Negative Online Inquiry
KO09487 GSTP1 Knockout cell line (HCT 116) Human GSTP1 1:2~1:4 Negative Online Inquiry
KO09488 GSTP1 Knockout cell line (HEK293) Human GSTP1 1:3~1:6 Negative Online Inquiry
KO09489 GSTP1 Knockout cell line (A549) Human GSTP1 1:3~1:4 Negative Online Inquiry

Background

GSTP1 Gene Knockout Cell Lines are specialized biological reagents engineered to facilitate the study of the GSTP1 gene, which encodes for Glutathione S-Transferase Pi 1, a key enzyme involved in cellular detoxification processes. These cell lines are created through precise gene-editing techniques, rendering them deficient in GSTP1 expression. This knockout model allows researchers to investigate the physiological and pathological roles of GSTP1, particularly its implications in cancer development, drug resistance, and oxidative stress responses.

The key functions of GSTP1 include detoxification of electrophilic compounds and regulation of intracellular redox status. In the absence of GSTP1, cellular responses to reactive oxygen species and xenobiotics can be dramatically altered, enabling researchers to elucidate metabolic pathways and therapeutic targets. By studying these cell lines, scientists can better understand the mechanisms underlying various diseases, assess drug efficacy, and explore novel therapeutic interventions.

From both a research and clinical perspective, GSTP1 Gene Knockout Cell Lines are invaluable tools. They represent a significant advancement in the field of pharmacogenomics, enabling high-throughput screening of drug compounds and the development of personalized medicine strategies. Researchers can leverage these models to identify biomarkers for better patient stratification in cancer therapies or assess the impact of environmental stressors on human health.

What sets our GSTP1 Gene Knockout Cell Lines apart from alternative products is their rigorous validation and consistent performance across experimental conditions. We ensure that our cell lines maintain genomic integrity and exhibit robust phenotypic characteristics. Additionally, our commitment to quality control and customer support ensures that researchers can rely on our products for reproducible results in their studies.

We pride ourselves on our deep expertise in the field of cellular and molecular biology, backed by years of experience in developing cutting-edge biological products. This enables us to provide researchers and clinicians with reliable tools that propel their scientific discoveries and clinical applications forward.

Please note that all services are for research use only. Not intended for any clinical use.

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