GRIK2 Knockout Cell Lines

Gene: GRIK2

Official Full Name: glutamate ionotropic receptor kainate type subunit 2provided by HGNC

Gene Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008]

Get A Quote

Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO37510	GRIK2 Knockout cell line (HeLa)	Human	GRIK2	1:3~1:6	Negative	Online Inquiry

Background

GRIK2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the GRIK2 gene, encoding for the glutamate receptor ionotropic kainate 2. This knockout approach allows researchers to study the functional role of GRIK2 in various physiological and pathological processes, including neurodevelopment, pain signaling, and synaptic transmission. By using CRISPR-Cas9 gene editing technology, these cell lines provide a precise method to generate and maintain cells with complete gene deletion, leading to a more accurate representation of the GRIK2-related biological pathways.

The GRIK2 gene plays a crucial role in mediating excitatory neurotransmission within the central nervous system. As a prominent component of the kainate receptor subtype, its knockout can elucidate the mechanisms underlying synaptic plasticity and the pathophysiology of numerous neurological disorders, such as epilepsy and schizophrenia. In clinical research, these cell lines are invaluable for drug discovery processes, enabling the screening of therapeutic compounds targeting GRIK2-related signaling pathways, thereby accelerating the development of new neuropsychological treatments.

The exclusive advantages of GRIK2 Gene Knockout Cell Lines include their customizable nature and reproducibility, which surpass traditional knockout strategies that often suffer from off-target effects. By providing a standardized model, this product ensures consistent results across experiments, fostering improved comparability. Additionally, researchers will find that these cell lines allow for straightforward establishment of functional assays, such as calcium imaging and electrophysiological recordings.

With the rising demand for precise and reliable biological models, GRIK2 Gene Knockout Cell Lines represent a critical advancement for neuroscientists and pharmacologists alike. Their ability to streamline research efforts while offering deeper insights into the complexities of receptor dynamics positions this product as an essential tool in advancing our understanding of GRIK2 function.

Our company boasts deep expertise in genomic technologies and a commitment to providing high-quality biological products. By integrating cutting-edge science with robust support, we equip researchers with the necessary tools to make groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.