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GPT Knockout Cell Lines

Gene: GPT

Official Full Name: glutamic--pyruvic transaminaseprovided by HGNC

Gene Summary: This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02821 GPT Knockout cell line (HEK293) Human GPT 1:3~1:6 Negative Online Inquiry

Background

GPT Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of gene function and the biological mechanisms underlying various diseases. Utilizing advanced CRISPR/Cas9 technology, these cell lines possess targeted deletions in the GPT gene, enabling researchers to examine knockdown effects on cellular pathways, metabolic processes, and responses to pharmacological agents. This precision allows for an in-depth understanding of the gene's role in health and disease, particularly regarding its implications in disorders such as diabetes and metabolic syndromes.

The inherent functionality of GPT Gene Knockout Cell Lines lies in their capacity to replicate the loss-of-function scenario of the GPT gene in a controlled environment. By providing a robust platform for functional genomics, these cell lines empower scientists to dissect cellular signaling pathways, elucidate metabolic disruptions, and evaluate gene-gene interactions. This capability promotes advancements in drug discovery, biomarker identification, and therapeutic development within both academic and clinical research settings.

One of the standout advantages of GPT Gene Knockout Cell Lines is their versatility in experimental applications. Compared to traditional genetic manipulation methods, the CRISPR-mediated approach offers higher efficiency, specificity, and reproducibility. Researchers can confidently utilize these cell lines for a variety of assays, including high-throughput screening and therapeutic intervention studies, enhancing the reliability of their findings.

For researchers and clinicians, the value of GPT Gene Knockout Cell Lines is amplified by the ability to translate basic research into clinical applications. Unraveling the complexities of gene-function relationships accelerates the path toward innovative treatments and personalized medicine strategies. By leveraging these cell lines, users are equipped with the tools necessary to make significant advancements in understanding gene-related diseases.

Our company is dedicated to providing high-quality biological products that address the evolving needs of the scientific community. With a commitment to innovation and precision, we offer GPT Gene Knockout Cell Lines as part of an extensive portfolio designed to support groundbreaking research and transformative discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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