Gene: GPS2
Official Full Name: G protein pathway suppressor 2provided by HGNC
Gene Summary: This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04265 | GPS2 Knockout cell line (HeLa) | Human | GPS2 | 1:3~1:6 | Negative | Online Inquiry |
KO04266 | GPS2 Knockout cell line (HCT 116) | Human | GPS2 | 1:2~1:4 | Negative | Online Inquiry |
KO04267 | GPS2 Knockout cell line (HEK293) | Human | GPS2 | 1:3~1:6 | Negative | Online Inquiry |
KO04268 | GPS2 Knockout cell line (A549) | Human | GPS2 | 1:3~1:4 | Negative | Online Inquiry |
GPS2 Gene Knockout Cell Lines are specialized in vitro models that have been engineered to possess a targeted deletion of the GPS2 gene, crucial for studying various biological processes and disease pathways. By utilizing CRISPR/Cas9 technology, these cell lines facilitate the precise knockout of GPS2, thereby allowing researchers to investigate its role in cellular function, signaling pathways, and disease mechanisms, particularly those related to cancer and metabolic disorders.
The primary function of GPS2 Gene Knockout Cell Lines lies in their ability to help elucidate the biological impact of GPS2 depletion on cellular behavior. Researchers can analyze changes in gene expression, protein interactions, and metabolic processes, using these models to unravel the complex regulatory networks that GPS2 participates in. This mechanistic insight can be instrumental in understanding how dysregulation of GPS2 contributes to pathological conditions, providing a foundation for the development of novel therapeutic strategies.
In research and clinical settings, the significant importance of GPS2 Knockout Cell Lines is seen in their application in drug discovery, biomarker identification, and functional genomics. By leveraging these models, scientists can assess drug efficacy and specificity by monitoring how treatments influence GPS2 knockout cells compared to their wild-type counterparts.
Compared to traditional cell lines or other gene knockout models, GPS2 Gene Knockout Cell Lines offer distinct advantages, including a streamlined approach to gene editing, high reproducibility, and the ability to mimic pathophysiological conditions more closely. These features enhance the reliability of experimental data and can lead to more relevant clinical insights.
The value of GPS2 Gene Knockout Cell Lines is profound for researchers and clinicians who are focused on advancing our understanding of molecular biology and developing targeted therapies. Their precise engineering allows for robust experimentation that can accelerate discoveries in biomedical research, making them an essential tool in the arsenal of life science research.
Our company specializes in providing high-quality biological products, utilizing the latest technologies and methodologies to support cutting-edge research. Our GPS2 Gene Knockout Cell Lines are manufactured with precision and care, ensuring that researchers have reliable tools to push the boundaries of scientific knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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