Gene: GPR180
Official Full Name: G protein-coupled receptor 180provided by HGNC
Gene Summary: This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17283 | GPR180 Knockout cell line (HeLa) | Human | GPR180 | 1:3~1:6 | Negative | Online Inquiry |
KO17284 | GPR180 Knockout cell line (HCT 116) | Human | GPR180 | 1:2~1:4 | Negative | Online Inquiry |
KO17285 | GPR180 Knockout cell line (HEK293) | Human | GPR180 | 1:3~1:6 | Negative | Online Inquiry |
KO17286 | GPR180 Knockout cell line (A549) | Human | GPR180 | 1:3~1:4 | Negative | Online Inquiry |
GPR180 Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the GPR180 gene, which plays a crucial role in various physiological processes, including immune response and inflammatory signaling. By creating knockout models, researchers can effectively eliminate GPR180 expression, allowing for in-depth analysis of its functional role within cellular environments.
The primary mechanism of these cell lines involves the use of CRISPR-Cas9 technology, which introduces specific double-strand breaks in the GPR180 gene. This targeted gene editing results in frameshifts or deletions, leading to a complete loss of GPR180 protein function. Researchers can then observe the phenotypic consequences of GPR180 knockout on various biological pathways, elucidating its contributions to immune modulation, cellular growth, and inflammation.
The scientific significance of GPR180 Gene Knockout Cell Lines is underscored by their potential applications in both basic research and clinical settings. They are invaluable for studying the gene's role in disease models, particularly concerning autoimmune disorders and cancer, where GPR180’s modulation may influence disease progression and therapeutic responses. Particularly in drug development, these cell lines provide a platform to test the efficacy of new treatments targeting GPR180 pathways.
Distinct advantages of our GPR180 Gene Knockout Cell Lines include their validated knockout efficiency and reproducibility, ensuring consistent results across experiments. Unlike alternative methods that may rely on less efficient gene silencing techniques, our knockout cell lines guarantee a permanent and complete loss of function. This specificity enhances the reliability and contextual relevance of the data obtained from experiments, offering an edge in experimental accuracy.
For researchers and clinicians seeking robust tools for gene function studies or therapeutic exploration, GPR180 Gene Knockout Cell Lines present unparalleled value. By enabling precise insights into GPR180’s role in health and disease, our product stands out as an essential resource in the research community.
Furthermore, our company brings years of expertise in developing high-quality biological products. We are committed to providing innovative tools that empower scientific discovery and contribute to advancements in medical research.
Please note that all services are for research use only. Not intended for any clinical use.
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