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GPR146 Knockout Cell Lines

Gene: GPR146

Official Full Name: G protein-coupled receptor 146provided by HGNC

Gene Summary: Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cholesterol biosynthetic process. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30623 GPR146 Knockout cell line (HCT 116) Human GPR146 1:2~1:4 Negative Online Inquiry
KO30624 GPR146 Knockout cell line (HEK293) Human GPR146 1:3~1:6 Negative Online Inquiry

Background

GPR146 Gene Knockout Cell Lines are engineered cellular models specifically designed to provide a deep understanding of the GPR146 gene's biological functions and its role in various physiological and pathological processes. These cell lines are developed using CRISPR-Cas9 gene-editing technology, which allows for precise deletion of the GPR146 gene, effectively creating a robust model for studying the implications of GPR146 loss-of-function in cell signaling and receptor biology.

The key functions of these knockout cell lines revolve around their ability to elucidate GPR146's role in modulating cellular responses involving inflammation, cell proliferation, and differentiation. By comparing the knockouts to wild-type counterparts, researchers can observe how the absence of GPR146 affects various signaling pathways and cellular behaviors, providing critical insights into its molecular mechanisms.

Scientifically, GPR146 has been implicated in multiple pathways relevant to disease states such as cancer and autoimmune disorders, making these cell lines remarkably valuable in clinical research. These models are crucial for the identification of potential therapeutic targets and the development of novel pharmacological interventions.

What sets GPR146 Gene Knockout Cell Lines apart from traditional models is their specificity and reliability. While other models might not adequately mimic GPR146 loss or may incorporate confounding variables, these knockout lines offer clear, interpretable results, leading to improved experimental consistency. Furthermore, their ease of use in high-throughput screening assays allows researchers to accelerate their discovery processes and enhance productivity.

In summary, GPR146 Gene Knockout Cell Lines represent a significant advancement for researchers and clinicians alike, providing a specialized tool for in-depth analysis of GPR146's biological significance. Our company prides itself on delivering high-quality, precisely engineered biological products that empower scientific breakthroughs, underpinned by a commitment to innovation and excellence in research tools.

Please note that all services are for research use only. Not intended for any clinical use.

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