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GPM6B Knockout Cell Lines

Gene: GPM6B

Official Full Name: glycoprotein M6Bprovided by HGNC

Gene Summary: This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37563 GPM6B Knockout cell line (HeLa) Human GPM6B 1:3~1:6 Negative Online Inquiry
KO37564 GPM6B Knockout cell line (HCT 116) Human GPM6B 1:2~1:4 Negative Online Inquiry
KO37565 GPM6B Knockout cell line (HEK293) Human GPM6B 1:3~1:6 Negative Online Inquiry

Background

GPM6B Gene Knockout Cell Lines represent a crucial development in the field of molecular biology, serving as a powerful tool for investigating the function of the GPM6B gene. These engineered cell lines have undergone precise gene editing techniques, such as CRISPR-Cas9, to create a loss-of-function model that allows researchers to study the phenotypic and molecular consequences of GPM6B deletion. This approach facilitates the exploration of the gene’s role in neuronal development, signaling pathways, and potential implications in neurodegenerative diseases.

The mechanisms of action for GPM6B Gene Knockout Cell Lines hinge on the elimination of the GPM6B protein, which is known to play a significant role in synaptic plasticity and neuronal communication. By providing a model in which GPM6B is non-functional, researchers can closely monitor changes in cellular responses, signaling cascades, and overall cell behavior. This is particularly important in studies aimed at understanding various neurological disorders where GPM6B has been implicated, such as Alzheimer’s disease.

In research and clinical settings, these knockout cell lines are invaluable for drug testing, biomarker discovery, and therapeutic development. Their applications span from basic research to translational science, offering insights that could lead to innovative treatment strategies for conditions that remain difficult to manage.

Compared to traditional wild-type cell lines, GPM6B Gene Knockout Cell Lines enable more accurate assessments of gene function without the confounding effects of gene expression variability. Moreover, they can be utilized in high-throughput screening applications, significantly accelerating the drug development process.

For researchers and clinicians committed to advancing the understanding of neurobiology and related diseases, GPM6B Gene Knockout Cell Lines provide a unique, reliable, and reproducible platform. Leveraging our extensive experience in gene editing technology, our company is dedicated to delivering high-quality biological products, ensuring researchers have the tools necessary to drive their investigations forward while maintaining the highest standards of scientific integrity.

Please note that all services are for research use only. Not intended for any clinical use.

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