GOT2 Knockout Cell Lines

GOT2 Gene Knockout Cell Lines are a specialized model system designed for the investigation of glutamate oxaloacetate transaminase 2 (GOT2) function in cellular physiology and disease. These genetically modified cell lines are characterized by the specific deletion of the GOT2 gene, which encodes a key enzyme involved in amino acid and carbohydrate metabolism. The knockout mechanism typically employs CRISPR-Cas9 technology, ensuring precise removal of the gene, which leads to the disruption of mitochondrial aspartate synthesis and subsequently affects the cellular metabolic balance.

The primary function of GOT2 involves the transamination process that plays a critical role in the tricarboxylic acid cycle and nitrogen metabolism. By utilizing this knockout model, researchers can precisely analyze the genetic and biochemical implications of loss of GOT2 function, aiding in the understanding of metabolic disorders, mitochondrial dysfunctions, and cancer metabolism. Furthermore, these cell lines provide a valuable platform for therapeutic research, including drug screening and biomarker development.

What sets our GOT2 Gene Knockout Cell Lines apart from traditional models is their unparalleled specificity and sensitivity, providing researchers with a powerful tool to dissect metabolic pathways with greater accuracy. The ability to examine the consequences of GOT2 deletion in cellular environments mirrors physiological conditions more closely than transient knockdown models, enhancing the reproducibility and reliability of experimental results.

These cell lines hold significant promise for elucidating the role of GOT2 in various diseases, thereby serving as a critical asset for both academic and clinical researchers seeking to innovate in biomedical sciences. Our commitment to advancing research quality is underpinned by rigorous quality control measures and comprehensive support for users, further affirming our position as a leader in the provision of biological products. With GOT2 Gene Knockout Cell Lines, you will be equipped to uncover new insights into metabolic regulation and therapeutic interventions.