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GNS Knockout Cell Lines

Gene: GNS

Official Full Name: glucosamine (N-acetyl)-6-sulfataseprovided by HGNC

Gene Summary: The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04576 GNS Knockout cell line (HeLa) Human GNS 1:3~1:6 Negative Online Inquiry
KO04577 GNS Knockout cell line (HCT 116) Human GNS 1:2~1:4 Negative Online Inquiry
KO04578 GNS Knockout cell line (HEK293) Human GNS 1:3~1:6 Negative Online Inquiry
KO04579 GNS Knockout cell line (A549) Human GNS 1:3~1:4 Negative Online Inquiry

Background

GNS Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of gene function by enabling precise gene disruption through homologous recombination or CRISPR-Cas9 methodologies. By creating cell lines in which specific genes are inactivated, researchers can analyze the resultant phenotypic changes, thereby comprehensively elucidating the biological role of those genes. This targeted approach allows scientists to investigate cellular pathways, disease mechanisms, and therapeutic targets in a controlled environment.

The primary mechanism behind these cell lines involves the introduction of genetic alterations that result in the loss of function of target genes. This is achieved with high specificity, ensuring that off-target effects are minimized. As a result, GNS Gene Knockout Cell Lines provide a robust platform for functional genomics studies, drug screening, and the validation of gene targets in a variety of biological contexts, including cancer research, developmental biology, and metabolic studies.

From a scientific standpoint, these cell lines represent a critical tool in the toolkit of modern biologists and clinicians. Their versatility makes them invaluable for research into genetically heterogeneous diseases, enabling the exploration of therapeutic interventions that can manipulate gene activity directly. Moreover, these knockout models are essential for the investigation of gene interactions, enabling scientists to build more accurate disease models, which can subsequently lead to advancements in personalized medicine.

What sets GNS Gene Knockout Cell Lines apart from traditional cell lines is their meticulously validated knockout efficiency and specificity. Each cell line undergoes rigorous quality control to ensure that the desired gene has been effectively disrupted, minimizing variability between experiments. Additionally, our customization options allow researchers to tailor cell lines to their specific research needs, which is often not available in alternative products.

For researchers and clinicians seeking reliable and precise cellular models to accelerate their discoveries, GNS Gene Knockout Cell Lines offer a scientifically grounded and user-friendly solution. Our dedication to advancing genetic research through state-of-the-art technology and unparalleled expertise ensures that our products meet the highest standards of quality and efficacy. Choose GNS for a partner in transformative biological discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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