Gene: GNRH1
Official Full Name: gonadotropin releasing hormone 1provided by HGNC
Gene Summary: This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37596 | GNRH1 Knockout cell line (HeLa) | Human | GNRH1 | 1:3~1:6 | Negative | Online Inquiry |
KO37597 | GNRH1 Knockout cell line (HCT 116) | Human | GNRH1 | 1:2~1:4 | Negative | Online Inquiry |
KO37598 | GNRH1 Knockout cell line (HEK293) | Human | GNRH1 | 1:3~1:6 | Negative | Online Inquiry |
KO37599 | GNRH1 Knockout cell line (A549) | Human | GNRH1 | 1:3~1:4 | Negative | Online Inquiry |
GNRH1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the function of the Gonadotropin-Releasing Hormone 1 (GNRH1) gene. This essential hormone plays a critical role in the endocrine regulation of reproductive function by stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. The GNRH1 gene knockout technology utilizes CRISPR/Cas9 gene-editing techniques to create precise genomic modifications, enabling researchers to study the consequences of GNRH1 deficiency in cellular models.
The primary functions of these knockout cell lines involve investigating the impact of reduced GNRH1 signaling on hormone biosynthesis and reproductive health. By analyzing these cell lines, scientists can elucidate the molecular pathways influenced by GNRH1, furthering our understanding of conditions linked to reproductive endocrinology, such as hypogonadism, infertility, and certain hormone-dependent cancers. These insights are invaluable for developing new therapeutic strategies and advancing reproductive medicine.
What sets GNRH1 Gene Knockout Cell Lines apart from conventional cell lines is their capacity to model specific diseases resulting from GNRH1 dysfunction. Researchers benefit from the unique ability to study treatment responses and hormonal interdependencies in a controlled environment. This product addresses a critical need for precise and versatile tools in biological research, enabling customized experimental designs that yield high-impact results.
By providing these knockout models, our company reaffirms its commitment to supporting the scientific community with innovative biological research tools. With our extensive expertise in cell line development, we ensure that each product meets stringent quality and performance standards, fostering advancements in research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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