Gene: GNG12
Official Full Name: G protein subunit gamma 12provided by HGNC
Gene Summary: Enables PDZ domain binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09011 | GNG12 Knockout cell line (HeLa) | Human | GNG12 | 1:3~1:6 | Negative | Online Inquiry |
KO09012 | GNG12 Knockout cell line (HCT 116) | Human | GNG12 | 1:2~1:4 | Negative | Online Inquiry |
KO09013 | GNG12 Knockout cell line (HEK293) | Human | GNG12 | 1:3~1:6 | Negative | Online Inquiry |
KO09014 | GNG12 Knockout cell line (A549) | Human | GNG12 | 1:3~1:4 | Negative | Online Inquiry |
GNG12 Gene Knockout Cell Lines are precisely engineered cellular models designed to study the function of the GNG12 gene, which encodes for a subunit of the G protein complex involved in various cellular signaling pathways. Utilizing advanced CRISPR-Cas9 gene editing techniques, these cell lines exhibit a homozygous knockout of the GNG12 gene, allowing researchers to investigate the physiological and pathological roles of GNG12 without the confounding effects of gene expression.
The primary mechanism of these gene knockout cell lines involves the disruption of the GNG12 gene, which leads to the absence of the corresponding protein. This alteration results in significant changes to G protein signaling cascades, which can influence numerous biological processes such as cell proliferation, differentiation, and apoptosis. By using these cell lines, researchers can develop a deeper understanding of GNG12's role in signal transduction and its implications in diseases, including cancer and heart conditions.
The scientific importance of GNG12 Gene Knockout Cell Lines lies in their applications for both basic research and clinical investigations. They can be employed in drug discovery, molecular biology studies, and functional genomics, providing valuable insights into complex biological systems and potential therapeutic targets.
What sets GNG12 Gene Knockout Cell Lines apart from alternative models is the precision offered by our proprietary editing protocols, ensuring high efficiency and reproducibility. Moreover, these cell lines are validated for multiple assays, providing versatility for diverse experimental setups.
For researchers and clinicians dedicated to uncovering the intricacies of cellular signaling and its implications in health and disease, GNG12 Gene Knockout Cell Lines represent an indispensable resource. Our commitment to high-quality biological products stems from years of expertise and innovation, positioning us as a trusted partner in advancing life sciences research.
Please note that all services are for research use only. Not intended for any clinical use.
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