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GNE Knockout Cell Lines

Gene: GNE

Official Full Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinaseprovided by HGNC

Gene Summary: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32373 GNE Knockout cell line (HeLa) Human GNE 1:3~1:6 Negative Online Inquiry
KO32374 GNE Knockout cell line (HCT 116) Human GNE 1:2~1:4 Negative Online Inquiry
KO32375 GNE Knockout cell line (HEK293) Human GNE 1:3~1:6 Negative Online Inquiry
KO32376 GNE Knockout cell line (A549) Human GNE 1:3~1:4 Negative Online Inquiry

Background

GNE Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted gene disruption, specifically designed to facilitate the study of gene function and the resultant phenotypic changes within a controlled environment. By employing advanced CRISPR-Cas9 technology or other genome-editing techniques, these cell lines provide researchers with a powerful tool for investigating gene activity, pathway dynamics, and the underlying mechanisms of various biological processes.

The primary functions of GNE Gene Knockout Cell Lines revolve around their ability to elucidate the role of specific genes by enabling the examination of loss-of-function phenotypes. Researchers can observe alterations in cellular behaviors, metabolic pathways, and signaling cascades which can be crucial in understanding disease states and therapeutic interventions. This information is invaluable, especially in fields such as cancer research, drug development, and regenerative medicine, where gene manipulation is central to the investigation of cellular responses and adaptability.

The scientific importance of GNE Gene Knockout Cell Lines lies in their versatility and applicability across various research domains. In clinical settings, they aid in the identification of potential drug targets, biomarker discovery, and the development of personalized medicine approaches. Moreover, these cell lines allow for high-throughput screening of compounds, expediting the drug discovery process while ensuring reproducibility and reliability of results.

What sets GNE Gene Knockout Cell Lines apart from traditional alternatives is their precision and specificity in gene editing, minimizing off-target effects and enhancing the consistency of experimental outcomes. Additionally, these cell lines are rigorously validated for efficiency and stability, providing researchers with a dependable resource that meets the highest standards of scientific integrity.

For researchers and clinicians alike, the value of GNE Gene Knockout Cell Lines extends beyond mere experimental tools; they represent an opportunity to drive innovation in biological research and therapeutic development. By enabling a more profound understanding of gene function and its implications, these cell lines help pave the way for novel insights into complex diseases.

Our company is dedicated to providing state-of-the-art products that support and propel scientific discoveries. With our expertise in genetic engineering and a robust portfolio of high-quality biological products, we are committed to equipping researchers with the tools they need to advance their work and achieve groundbreaking results.

Please note that all services are for research use only. Not intended for any clinical use.

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