Home / GLS2 Knockout Cell Lines

GLS2 Knockout Cell Lines

Gene: GLS2

Official Full Name: glutaminase 2provided by HGNC

Gene Summary: The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27774 GLS2 Knockout cell line (HeLa) Human GLS2 1:3~1:6 Negative Online Inquiry
KO27775 GLS2 Knockout cell line (HEK293) Human GLS2 1:3~1:6 Negative Online Inquiry

Background

GLS2 Gene Knockout Cell Lines are genetically engineered cell lines designed to provide researchers with valuable tools for studying the function of the GLS2 gene. This gene is known to play a critical role in glutamine metabolism, influencing cellular energy production and redox balance, which are vital for maintaining cellular homeostasis. By effectively knocking out the GLS2 gene, these cell lines enable scientists to investigate the consequences of its absence on various biological processes, including cellular proliferation, differentiation, and stress responses.

The mechanism of action of these knockout cell lines is rooted in CRISPR-Cas9 technology, allowing for precise and efficient gene editing. By disrupting the GLS2 gene, researchers can observe changes in metabolic pathways, assess alterations in cellular responses to nutrient availability, and evaluate potential therapeutic targets for diseases linked to dysregulated glutamine metabolism. The ability to create and utilize GLS2 knockout models offers significant advantages for advancing our understanding of cancer biology, neurodegenerative diseases, and metabolic disorders, where glutamine plays a pivotal role.

The scientific importance of GLS2 Gene Knockout Cell Lines extends to both basic and applied research, as investigators can leverage these tools for drug discovery, biomarker identification, and elucidating the molecular mechanisms underlying disease. Compared to traditional knockout methods, which can be time-consuming and less reliable, our cell lines are optimally characterized for reproducibility and efficiency, expediting the research process while ensuring high-quality results.

For researchers and clinicians focused on metabolic research, cancer therapies, and therapeutic innovations, GLS2 Gene Knockout Cell Lines present a unique opportunity to contribute to advancements in the field. With a commitment to providing cutting-edge biological products, our company utilizes robust biotechnological platforms to deliver products that meet the rigorous demands of the scientific community, ensuring our customers have access to the most reliable and effective research tools available.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.