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GLRX Knockout Cell Lines

Gene: GLRX

Official Full Name: glutaredoxinprovided by HGNC

Gene Summary: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37621 GLRX Knockout cell line (HeLa) Human GLRX 1:3~1:6 Negative Online Inquiry
KO37622 GLRX Knockout cell line (HCT 116) Human GLRX 1:2~1:4 Negative Online Inquiry
KO37623 GLRX Knockout cell line (HEK293) Human GLRX 1:3~1:6 Negative Online Inquiry
KO37624 GLRX Knockout cell line (A549) Human GLRX 1:3~1:4 Negative Online Inquiry

Background

GLRX Gene Knockout Cell Lines are meticulously designed cellular models that are engineered to facilitate the study of gene function and the underlying mechanisms of diseases associated with oxidative stress and redox biology. These knockout cell lines specifically lack the expression of the glutaredoxin (GLRX) gene, a critical component involved in regulating cellular antioxidant defense systems and maintaining redox homeostasis.

The primary function of GLRX is to reduce protein disulfides and facilitate cellular antioxidant responses. By utilizing these knockout cell lines, researchers can elucidate the specific pathways affected by GLRX deficiency, investigate the role of oxidative stress in various diseases, and assess potential therapeutic interventions. The absence of GLRX permits a deeper understanding of its contributions to cellular signaling and metabolism, thereby providing insights into how the dysregulation of redox balance can lead to conditions such as cancer, neurodegeneration, and cardiovascular diseases.

In research and clinical applications, GLRX Gene Knockout Cell Lines hold significant scientific importance. They serve as valuable platforms for drug discovery, therapeutic validation, and biomarker development. Furthermore, they enable clinicians and researchers to explore novel interventions that can restore redox balance and mitigate oxidative damage in clinical settings.

The unique advantage of GLRX Gene Knockout Cell Lines lies in their specificity and reliability compared to other cell models. They provide a controlled environment that allows for precise manipulation of oxidative stress parameters, yielding reproducible results that can be easily interpreted. This distinct utility makes them indispensable for bridging the gap between basic research and clinical application.

For researchers and clinicians aiming to understand oxidative stress-related pathologies or develop targeted therapies, GLRX Gene Knockout Cell Lines are an invaluable resource. With a commitment to advancing scientific discovery, our company specializes in high-quality biological products that empower the research community. Our expertise ensures that you have access to cutting-edge tools designed to drive innovation and enhance research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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