Gene: GLCE
Official Full Name: glucuronic acid epimeraseprovided by HGNC
Gene Summary: Enables calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Implicated in cerebrovascular disease and hypertension. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04079 | GLCE Knockout cell line (HeLa) | Human | GLCE | 1:3~1:6 | Negative | Online Inquiry |
KO04080 | GLCE Knockout cell line (HCT 116) | Human | GLCE | 1:2~1:4 | Negative | Online Inquiry |
KO04081 | GLCE Knockout cell line (HEK293) | Human | GLCE | 1:3~1:6 | Negative | Online Inquiry |
KO04082 | GLCE Knockout cell line (A549) | Human | GLCE | 1:3~1:4 | Negative | Online Inquiry |
GLCE Gene Knockout Cell Lines are specifically engineered cell lines lacking the GLCE gene, which encodes for the enzyme glucuronyl CoA epimerase. This product serves as a valuable tool for researchers looking to study the physiological and pathological roles of glycosaminoglycans, particularly in the context of tissue development, cancer biology, and tissue engineering.
These cell lines function by enabling the investigation of the specific contributions of the GLCE gene to cellular processes such as proliferation, adhesion, and signaling pathways. By providing a model system that eliminates the normal function of GLCE, researchers can explore the dynamics of glycan biosynthesis and their regulatory roles in cellular interactions and extracellular matrix composition.
The scientific importance of GLCE Gene Knockout Cell Lines is profound, as they allow for the dissection of complex biological processes that depend on glycosaminoglycan modification. Applications in research are extensive; they facilitate studies on developmental biology, cancer metastasis, and even therapeutic drug testing. In clinical settings, the insights gained from these models could inform the development of targeted therapies and biomaterials that integrate seamlessly with existing biological pathways.
One significant advantage of our GLCE Gene Knockout Cell Lines over alternatives is their high fidelity and reproducibility, which ensures consistent experimental outcomes. This product has been optimized for various assays including but not limited to gene expression analysis, protein interactions, and drug response evaluations. Additionally, our knockout lines are validated against off-target effects, which enhances their reliability and trustworthiness as a research tool.
For researchers and clinicians looking to deepen their understanding of glycosaminoglycans and their biological implications, investing in GLCE Gene Knockout Cell Lines represents a strategic choice. This product not only opens new avenues for discovery but also supports the advancement of therapeutic interventions that rely on precise molecular interactions.
Our company is committed to providing high-quality, scientifically validated products designed to accelerate research and innovation in the life sciences. With a focus on cutting-edge technologies and expert support, we are here to empower your scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.