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GJC2 Knockout Cell Lines

Gene: GJC2

Official Full Name: gap junction protein gamma 2provided by HGNC

Gene Summary: This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO17378 GJC2 Knockout cell line (HeLa) Human GJC2 1:3~1:6 Negative Online Inquiry
KO17379 GJC2 Knockout cell line (HEK293) Human GJC2 1:3~1:6 Negative Online Inquiry

Background

GJC2 Gene Knockout Cell Lines represent a cutting-edge tool for researchers studying the functional implications of the GJC2 gene, known for its role in gap junction intercellular communication. By utilizing CRISPR-Cas9 genome editing technology, these cell lines are specifically engineered to contain disruptions in the GJC2 gene, allowing scientists to elucidate the gene's contribution to various biological processes and disease states. The knockout mechanism involves the insertion of a targeted mutation that prevents GJC2 from producing a functional protein, thus disabling its critical functions in cellular signaling pathways.

The scientific importance of GJC2 Gene Knockout Cell Lines spans numerous research domains, including developmental biology, neurobiology, and pathology. For instance, aberrations in gap junction functionality have been implicated in a variety of conditions, such as neurological disorders and certain cancers. Employing these knockout models can facilitate the exploration of GJC2's role in disease progression and its potential as a therapeutic target. Moreover, they are vital for high-throughput screenings and drug discovery applications.

One of the key advantages of our GJC2 Gene Knockout Cell Lines is their specificity and reliability compared to conventional methods of gene silencing. Many alternatives, such as siRNA or shRNA approaches, may inadvertently affect off-target genes, leading to ambiguous results. Our knockout models, however, provide a clean genetic background, ensuring more straightforward interpretation of experimental outcomes. Furthermore, the availability of these cell lines allows for reproducibility and consistency, essential for advancing research findings.

Researchers and clinicians will find significant value in our GJC2 Gene Knockout Cell Lines as they provide a robust platform for dissecting the molecular underpinnings of conditions associated with GJC2 dysfunction. The ability to conduct mechanistic studies and investigate potential interventions is crucial in the quest for new therapeutic strategies.

Our company is committed to advancing biomedical research through the provision of high-quality biological products. With our expertise in genetics and cell line development, we empower scientists to unlock new discoveries that pave the way for innovative health solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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