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GIGYF1 Knockout Cell Lines

Gene: GIGYF1

Official Full Name: GRB10 interacting GYF protein 1provided by HGNC

Gene Summary: This gene encodes a member of the gyf family of adaptor proteins. The encoded protein contains a gyf protein interaction domain. It binds growth factor receptor bound 10, another adaptor protein that binds activated insulin-like growth factor 1 and insulin receptors and regulates receptor signaling. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20553 GIGYF1 Knockout cell line (HeLa) Human GIGYF1 1:3~1:6 Negative Online Inquiry
KO20554 GIGYF1 Knockout cell line (HCT 116) Human GIGYF1 1:2~1:4 Negative Online Inquiry
KO20555 GIGYF1 Knockout cell line (HEK293) Human GIGYF1 1:3~1:6 Negative Online Inquiry
KO20556 GIGYF1 Knockout cell line (A549) Human GIGYF1 1:3~1:4 Negative Online Inquiry

Background

GIGYF1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically modified to eliminate the expression of the GIGYF1 gene, which encodes a crucial protein involved in cellular signaling and translation regulation. These knockout models are invaluable for studying the functional roles of GIGYF1 in various biochemical pathways, offering insights into its contributions to processes such as cellular growth, proliferation, and apoptosis.

The primary mechanism of GIGYF1 revolves around its interactions with several signaling proteins and RNA molecules, influencing the mTOR pathway and impacting protein synthesis. Disruption of GIGYF1 function through knockout techniques allows researchers to dissect these signaling networks, providing clarity on how alterations in GIGYF1 may contribute to various diseases, including cancer and metabolic disorders. Additionally, specific GIGYF1 knockout cell lines can facilitate the exploration of drug resistance mechanisms and potential therapeutic targets, enhancing our understanding of disease mechanisms at a molecular level.

The scientific importance of these cell lines extends far beyond simple genetic studies; they serve as a critical resource in both research and clinical settings. In laboratories focused on drug discovery, GIGYF1 knockout lines can be employed to screen new therapeutic agents, while in clinical research, they provide models to assess the efficacy and safety of potential treatments targeting related pathways.

A significant advantage of GIGYF1 Gene Knockout Cell Lines is their specificity and reliability. By offering the ability to reliably control for the effects of GIGYF1, researchers can obtain reproducible results that are free from the confounding impacts seen with other methods of gene alteration. This specificity stands in contrast to alternative models, such as those utilizing knockdown techniques, which may only reduce protein levels rather than completely abrogate expression. Furthermore, these knockout lines are meticulously validated for effective gene disruption, ensuring high confidence in experimental outcomes.

For researchers and clinicians striving to uncover the nuances of gene function, GIGYF1 Gene Knockout Cell Lines represent an essential tool that can lead to significant advancements in understanding disease mechanisms and identifying novel therapeutic interventions. Our company prides itself on delivering high-quality, meticulously developed genetic tools, including these knockout lines, backed by a strong foundation in molecular biology and a commitment to supporting scientific progress.

Please note that all services are for research use only. Not intended for any clinical use.

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