Gene: GEN1
Official Full Name: GEN1 Holliday junction 5' flap endonucleaseprovided by HGNC
Gene Summary: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions, which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition, this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17405 | GEN1 Knockout cell line (HeLa) | Human | GEN1 | 1:3~1:6 | Negative | Online Inquiry |
KO17406 | GEN1 Knockout cell line (HCT 116) | Human | GEN1 | 1:2~1:4 | Negative | Online Inquiry |
KO17407 | GEN1 Knockout cell line (HEK293) | Human | GEN1 | 1:3~1:6 | Negative | Online Inquiry |
KO17408 | GEN1 Knockout cell line (A549) | Human | GEN1 | 1:3~1:4 | Negative | Online Inquiry |
GEN1 Gene Knockout Cell Lines are meticulously designed cellular models that enable precise gene disruption through targeted genome editing techniques, such as CRISPR-Cas9 or conventional homologous recombination. These knockout cell lines have been engineered to lack specific genes of interest, facilitating the study of gene function and associated phenotypic changes. By exploiting the robust mechanisms of genetic manipulation, GEN1 Cell Lines provide a powerful tool for elucidating gene roles in various biological processes, including cell signaling, metabolism, and disease progression.
The core functionality of GEN1 Cell Lines lies in their ability to simulate loss-of-function conditions, allowing researchers to analyze the resultant biological impact on cellular behavior, gene expression profiles, and metabolic pathways. This feature is particularly vital in elucidating complex gene interactions and assessing therapeutic targets for various conditions, including cancer, genetic disorders, and metabolic diseases.
From a scientific perspective, GEN1 Knockout Cell Lines are invaluable in both basic and applied research settings. Their applications extend to drug discovery, biomarker validation, and disease modeling, making them essential for advancing our understanding of molecular mechanisms and therapeutic interventions.
What sets GEN1 apart from other gene knockout resources is the high fidelity of gene editing achieved, leading to complete genetic ablation without off-target effects. This precision ultimately translates to reliable experimental outcomes, thereby enhancing the reproducibility of scientific data. Furthermore, each cell line is thoroughly characterized and validated, providing assurance of consistency and quality in experimental applications.
For researchers and clinicians seeking to explore gene function in detail, the value of GEN1 lies in its ability to streamline experimental processes and yield meaningful insights into genetic contributions to health and disease. The product’s reliability and specificity position it as an essential asset in modern biomedical research.
Our company, renowned for its commitment to innovation in biotechnological solutions, brings you GEN1 Gene Knockout Cell Lines, backed by years of expertise in genetic engineering and cell biology. Our dedication to quality ensures that you receive top-tier scientific resources to advance your research initiatives effectively.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.