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GEM Knockout Cell Lines

Gene: GEM

Official Full Name: GTP binding protein overexpressed in skeletal muscleprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37680 GEM Knockout cell line (HCT 116) Human GEM 1:2~1:4 Negative Online Inquiry
KO37681 GEM Knockout cell line (HEK293) Human GEM 1:3~1:6 Negative Online Inquiry
KO37682 GEM Knockout cell line (A549) Human GEM 1:3~1:4 Negative Online Inquiry

Background

GEM Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the functional analysis of various genes by systematically eliminating their expression. These cell lines are derived from established and widely-used human or murine cell backgrounds, providing a robust platform for gene function studies. Using CRISPR/Cas9 technology or other advanced gene-editing techniques, GEM Gene Knockout Cell Lines offer precise genetic modifications that allow researchers to investigate the roles of individual genes in cellular processes, such as proliferation, differentiation, and apoptosis.

The primary function of these cell lines is to create a controlled environment where specific gene deletions can help elucidate gene function and identify gene-targeted therapeutic strategies. By enabling researchers to study the phenotypic consequences of gene loss, these knockout cell lines become critical tools in both basic and applied biological research, including drug discovery, cancer research, and the development of gene therapies.

The scientific importance of GEM Gene Knockout Cell Lines lies in their ability to provide insights into gene function that are invaluable in understanding disease mechanisms and identifying potential targets for intervention. In clinical research settings, these models can be imperative for preclinical testing of therapeutics, allowing for the evaluation of drug efficacy in a genetically relevant context.

Compared to traditional knockdown approaches, GEM Gene Knockout Cell Lines offer permanent and stable genetic modifications, reducing variability and circumventing the transient expression challenges associated with RNA interference (RNAi) methods. This permanence ensures that researchers can conduct long-term studies that provide more reliable data. Additionally, these cell lines come with extensive validation to confirm the efficiency of the knockout, ensuring high quality and reproducibility in experimental outcomes.

GEM Gene Knockout Cell Lines are highly valuable for researchers and clinicians looking to generate reliable insights into gene function, paving the way for novel therapeutic discoveries. With a commitment to innovation and quality, our company brings extensive expertise in the development of biological products, ensuring that researchers have access to cutting-edge tools that enhance their capability to advance scientific understanding and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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