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GBP3 Knockout Cell Lines

Gene: GBP3

Official Full Name: guanylate binding protein 3provided by HGNC

Gene Summary: This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03311 GBP3 Knockout cell line (HeLa) Human GBP3 1:3~1:6 Negative Online Inquiry
KO03312 GBP3 Knockout cell line (HCT 116) Human GBP3 1:2~1:4 Negative Online Inquiry
KO03313 GBP3 Knockout cell line (A549) Human GBP3 1:3~1:4 Negative Online Inquiry

Background

GBP3 Gene Knockout Cell Lines are sophisticated biological systems engineered to selectively disrupt the GBP3 gene, which is known for its role in immune response modulation and cellular signaling pathways. These knockout cell lines are generated through state-of-the-art CRISPR-Cas9 technology, ensuring precise genetic modifications that allow for the investigation of the GBP3 gene's function in various biological contexts.

The primary mechanism of these cell lines relies on the targeted editing of the GBP3 gene, resulting in a complete loss of its expression. This disruption allows researchers to examine the downstream effects on cellular processes such as cytokine production, immune cell differentiation, and signaling cascades typically influenced by GBP3. By utilizing these cell lines, scientists can elucidate the gene's contributions to disease mechanisms, particularly in contexts such as cancer biology, autoimmune disorders, and infectious diseases.

The scientific importance of GBP3 Gene Knockout Cell Lines lies in their ability to provide insights into the role of GBP3 in both basic biology and translational research. They are invaluable tools for drug discovery, biomarker development, and understanding immune system regulations in health and disease. Compared to alternative products, such as RNA interference approaches, knockout cell lines offer a permanent genetic alteration, allowing for long-term studies of gene function without the variability associated with transient transfection methods.

For researchers and clinicians, the GBP3 Gene Knockout Cell Lines represent a powerful asset in the quest to unravel complex biological questions and develop innovative therapeutic strategies. The precision offered by CRISPR technology ensures that these models are reliable and reproducible, facilitating rigorous scientific inquiry.

Developed by a dedicated team at our company, which specializes in cutting-edge genetic engineering and cell biology, the GBP3 Gene Knockout Cell Lines exemplify our commitment to providing high-quality biological tools that meet the diverse needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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