Home / GAB3 Knockout Cell Lines

GAB3 Knockout Cell Lines

Gene: GAB3

Official Full Name: GRB2 associated binding protein 3provided by HGNC

Gene Summary: This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25845 GAB3 Knockout cell line (HEK293) Human GAB3 1:3~1:6 Negative Online Inquiry

Background

GAB3 Gene Knockout Cell Lines are genetically modified cell lines that feature a targeted disruption of the GAB3 gene, which is known to play a crucial role in mediating signal transduction pathways associated with growth factor receptors. The knockout of GAB3 allows researchers to explore the gene's function and its involvement in various cellular processes, including proliferation, differentiation, and migration, particularly in the context of cancer and other diseases where aberrant signaling plays a key role.

The primary mechanism through which these cell lines operate is based on CRISPR-Cas9 technology, enabling precise editing of the genomic DNA to create deletions in the GAB3 gene. This allows for the study of the phenotypic changes arising from the loss of GAB3 expression, providing insights into its biological activities and potential therapeutic targets. Researchers can utilize these knockouts to investigate the pathways that regulate cellular behavior and the physiological consequences of GAB3 deficiency.

Scientifically, GAB3 Gene Knockout Cell Lines are invaluable in both basic research and clinical applications. They are particularly significant in the study of cancer biology, as GAB3 is implicated in oncogenic pathways. Furthermore, they can serve as models for testing drug responses and exploring potential therapeutic interventions targeting GAB3-associated pathways, making them highly relevant in the development of novel treatment strategies.

Compared to other cell lines or knockout models, the GAB3 Gene Knockout Cell Lines offer a specific and well-characterized platform for studying the implications of GAB3 loss. Their unique selling points include high reproducibility, robust cellular behavior analysis, and adaptability to various experimental conditions. These advantages make them a superior choice for researchers seeking reliable data on GAB3's role in various biological settings.

For researchers and clinicians looking to advance their understanding of cellular signal transduction and its implications in health and disease, GAB3 Gene Knockout Cell Lines provide a key resource to facilitate breakthrough discoveries. Our company specializes in developing high-quality biological products tailored to the needs of the scientific community, ensuring that our products, including these knockout cell lines, meet rigorous standards of quality and reliability.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.