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FZD3 Knockout Cell Lines

Gene: FZD3

Official Full Name: frizzled class receptor 3provided by HGNC

Gene Summary: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11770 FZD3 Knockout cell line (HCT 116) Human FZD3 1:2~1:4 Negative Online Inquiry
KO11771 FZD3 Knockout cell line (HEK293) Human FZD3 1:3~1:6 Negative Online Inquiry
KO11772 FZD3 Knockout cell line (A549) Human FZD3 1:3~1:4 Negative Online Inquiry

Background

FZD3 Gene Knockout Cell Lines represent a novel and powerful tool for studying the function of the Frizzled-3 (FZD3) gene, a key component of the Wnt signaling pathway involved in various developmental processes and cell differentiation. By employing advanced CRISPR/Cas9 gene-editing technology, these cell lines have been engineered to disrupt the expression of the FZD3 gene, allowing researchers to discern the effects of FZD3 loss on cellular behavior, signaling cascades, and developmental biology.

The primary function of these knockout cell lines is to facilitate the exploration of the biological roles of FZD3 by providing a controlled environment in which the gene is absent. This enables comparative studies against wild-type cells, helping to elucidate the role of FZD3 in cellular processes such as proliferation, migration, and stem cell differentiation. Researchers can employ these models to investigate the alterations in cellular signaling events initiated by Wnt ligands and their downstream effects on gene expression.

Scientifically, the availability of FZD3 Gene Knockout Cell Lines is paramount for advancing research in developmental biology, cancer research, and regenerative medicine. Given the established link between aberrant Wnt signaling and various pathologies, including cancers and developmental disorders, the utility of these models in therapeutic exploration and drug development is significant.

Compared to traditional knockout methods, the use of our FZD3 knockout cell lines offers precise gene disruption with high efficiency, resulting in reproducible studies. Unlike other available models that may rely on transient knockdown methods, these stable cell lines provide a robust platform for long-term studies.

For researchers and clinicians, such cell lines are indispensable in advancing an understanding of FZD3-related pathways and their implications in health and disease. With our commitment to high-quality biological products, our expertise ensures that these cell lines are developed under stringent conditions, providing reliable tools for your research needs. Our FZD3 Gene Knockout Cell Lines stand out as a key resource for innovative biological research, empowering users to yield groundbreaking findings in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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