Gene: FRZB
Official Full Name: frizzled related proteinprovided by HGNC
Gene Summary: The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37806 | FRZB Knockout cell line (HCT 116) | Human | FRZB | 1:2~1:4 | Negative | Online Inquiry |
FRZB Gene Knockout Cell Lines are advanced cellular models specifically engineered to lack expression of the Frizzled-related protein (FRZB), a critical molecule involved in the Wnt signaling pathway. The knockout of FRZB facilitates the study of its role in various biological processes, including cell proliferation, apoptosis, and differentiation. These cell lines serve as a powerful tool for elucidating the functional consequences of FRZB absence, thereby uncovering new insights into developmental biology and disease mechanisms.
The key mechanism by which FRZB Gene Knockout Cell Lines operate centers on the disruption of the Wnt signaling cascade, which is paramount for numerous cellular activities. By eliminating FRZB, researchers can assess the aggregated effects of unregulated Wnt activity, allowing for the detailed investigation of cellular behavior in response to growth factors and other environmental signals.
The scientific importance of these cell lines extends to both research and clinical applications. They are invaluable in studies of cancer, as aberrant Wnt signaling is frequently implicated in tumorigenesis. Additionally, they can be utilized for drug discovery, specifically for screening compounds that target Wnt-related pathways, potentially leading to novel therapeutic strategies.
Compared to other gene knockout models or wild-type cell lines, FRZB Gene Knockout Cell Lines offer a specific and refined focus on the functions of FRZB, enabling researchers to draw clearer connections between gene expression changes and phenotypic outcomes. This specificity enhances data integrity and analysis accuracy, making the product a superior choice for targeted studies.
For researchers, clinicians, and biotechnology companies, the application of FRZB Gene Knockout Cell Lines can significantly reduce experimental timelines while providing reliable, replicable data that advances understanding in the field. Our company leverages extensive expertise in cell line development and molecular biology, ensuring that you receive high-quality, validated cell lines tailored for innovative research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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