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FRS2 Knockout Cell Lines

Gene: FRS2

Official Full Name: fibroblast growth factor receptor substrate 2provided by HGNC

Gene Summary: Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06621 FRS2 Knockout cell line (HeLa) Human FRS2 1:3~1:6 Negative Online Inquiry
KO06622 FRS2 Knockout cell line (HCT 116) Human FRS2 1:2~1:4 Negative Online Inquiry
KO06623 FRS2 Knockout cell line (HEK293) Human FRS2 1:3~1:6 Negative Online Inquiry
KO06624 FRS2 Knockout cell line (A549) Human FRS2 1:3~1:4 Negative Online Inquiry

Background

FRS2 Gene Knockout Cell Lines are precision-engineered cellular models designed to study the functional implications of FRS2 (Fibroblast Growth Factor Receptor Substrate 2) gene disruptions. These cell lines are generated through advanced CRISPR-Cas9 gene-editing technology, effectively creating a loss-of-function model to facilitate in-depth investigations of cellular signaling pathways mediated by FRS2, a critical component in fibroblast growth factor (FGF) signaling.

The key function of the FRS2 gene involves its role in the transduction of extracellular signals initiated by FGFs, playing a pivotal part in cellular processes such as proliferation, differentiation, and survival. By utilizing these knockout cell lines, researchers can elucidate the downstream effects of FGF signaling disruption, allowing for insights into developmental biology, cancer progression, and tissue regeneration mechanisms.

From a scientific standpoint, FRS2 Gene Knockout Cell Lines are invaluable in both research and clinical applications. They serve as robust tools for studying the pathophysiology of conditions arising from aberrant FGF signaling, including various cancers and congenital disorders. These cell lines also provide a platform for evaluating therapeutic interventions, enabling researchers to identify and test novel drug candidates aimed at modulating FGF pathway activity.

What sets our FRS2 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability. Unlike pharmacological inhibitors which may have off-target effects, these cell lines allow for precise genetic manipulation, ensuring that observed phenotypic changes are directly attributable to FRS2 gene knockout. Additionally, our cell lines undergo rigorous quality control, ensuring consistency and reproducibility in experimental results.

For researchers and clinicians, the value of FRS2 Gene Knockout Cell Lines lies in their capability to significantly advance our understanding of FGF signaling and its implications in health and disease. By utilizing these models, users are better equipped to develop targeted therapies and uncover new biological insights.

Our company's commitment to excellence in molecular biology product offerings ensures that you receive high-quality, reliable cell lines that support your research needs. With our extensive expertise in genomics and cell biology, we remain dedicated to empowering the scientific community with the tools necessary to unravel complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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