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FRA10AC1 Knockout Cell Lines

Gene: FRA10AC1

Official Full Name: FRA10A associated CGG repeat 1provided by HGNC

Gene Summary: The protein encoded by this gene is a nuclear phosphoprotein of unknown function. This gene contains a tandem CGG repeat region within a CpG island that normally consists of 8-14 repeats but can expand to over 200 repeats. The repeat region is within the 5' UTR of some transcript variants, but is intronic to another variant. The expanded repeat allele is a fragile site and becomes hypermethylated, causing a reduction in gene expression. A disease phenotype has not been associated with expanded alleles. This gene is found within the rare FRA10A folate-sensitive fragile site. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30386 FRA10AC1 Knockout cell line (HeLa) Human FRA10AC1 1:3~1:6 Negative Online Inquiry
KO30387 FRA10AC1 Knockout cell line (HCT 116) Human FRA10AC1 1:2~1:4 Negative Online Inquiry
KO30388 FRA10AC1 Knockout cell line (HEK293) Human FRA10AC1 1:3~1:6 Negative Online Inquiry
KO30389 FRA10AC1 Knockout cell line (A549) Human FRA10AC1 1:3~1:4 Negative Online Inquiry

Background

FRA10AC1 Gene Knockout Cell Lines are highly specialized cellular models designed to facilitate the study of the FRA10AC1 gene's biological functions and its role in pathophysiological processes. These knockout cell lines are engineered using precise gene editing techniques that ensure the complete ablation of the FRA10AC1 gene, allowing researchers to investigate the consequences of its absence on cellular behavior, signaling pathways, and overall physiology.

The primary function of the FRA10AC1 Gene Knockout Cell Lines is to provide an experimental platform for assessing the gene's involvement in various biological processes, including cellular proliferation, differentiation, and response to stressors. By creating a controlled environment where the FRA10AC1 gene is not expressed, researchers can directly observe the changes in cell function and identify potential compensatory mechanisms or secondary pathways that may be activated in its absence. This insight is crucial for understanding its role in diseases such as cancer, where aberrant gene expression can contribute to malignancy.

The scientific importance of these knockout cell lines is underscored by their wide-ranging applications in basic research and clinical settings. They are invaluable for target validation in therapeutic development, biomarker discovery, and functional genomics studies. Furthermore, these cell lines facilitate high-throughput screening for drug responses, supporting the development of novel therapeutics aimed at modulating FRA10AC1-related pathways.

Compared to traditional cell lines, FRA10AC1 Gene Knockout Cell Lines offer unique advantages, including enhanced specificity in studying the gene's knockdown effects and greater reproducibility in experimental outcomes. Their robust genetic editing ensures that researchers can rely on these models as accurate reflections of the gene's functional loss, distinguishing them from alternatives that may have residual gene activity.

Choosing FRA10AC1 Gene Knockout Cell Lines can significantly enhance the value of research outcomes for scientists, clinicians, and biopharmaceutical companies alike, leading to more effective strategies for targeted therapies and improved patient care. Our company prides itself on our extensive expertise in developing advanced cellular models, ensuring researchers have access to high-quality, reliable products that meet the rigorous demands of modern biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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