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FOXA3 Knockout Cell Lines

Gene: FOXA3

Official Full Name: forkhead box A3provided by HGNC

Gene Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37320 FOXA3 Knockout cell line (HCT 116) Human FOXA3 1:2~1:4 Negative Online Inquiry
KO37321 FOXA3 Knockout cell line (HEK293) Human FOXA3 1:3~1:6 Negative Online Inquiry
KO37322 FOXA3 Knockout cell line (A549) Human FOXA3 1:3~1:4 Negative Online Inquiry

Background

FOXA3 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to disrupt the expression of the FOXA3 gene, a key regulator involved in various biological processes, including development, cellular differentiation, and organ function. By utilizing CRISPR-Cas9 technology, these cell lines enable researchers to investigate the functional role of FOXA3 in both normal physiological and pathological conditions.

The primary mechanism underlying these knockout cell lines involves the targeted deletion of the FOXA3 gene, leading to the complete absence of its protein product. This allows researchers to study the consequences of FOXA3 loss in various cell types, offering insights into its role as a transcription factor in metabolic regulation and tissue repair. Precise knockout models are invaluable for elucidating gene function, interactions, and downstream effects, which are critical for understanding complex biological pathways and potential therapeutic targets.

In scientific research and clinical settings, FOXA3 Gene Knockout Cell Lines have significant implications. They provide a powerful tool for deciphering the molecular mechanisms associated with diseases such as cancer, diabetes, and cardiovascular disorders. Additionally, these cell lines can be employed in drug discovery and validation processes, facilitating the identification of novel therapeutics that could modulate FOXA3-related pathways.

What sets our FOXA3 Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability. Each cell line undergoes rigorous validation to confirm the complete knockout, ensuring consistent experimental results. Moreover, our product offers a user-friendly application process, requiring minimal optimization for various research protocols.

Researchers and clinicians will find substantial value in these cell lines, as they not only accelerate the pathway to discovery but also contribute to advancements in personalized medicine. By understanding the implications of FOXA3 disruption, users can make precise interventions that pave the way for innovative healthcare solutions.

As a company dedicated to providing high-quality biological products, we leverage our extensive expertise in genetic engineering and cellular biology to offer researchers cutting-edge resources tailored for their experimental needs. Our commitment to innovation ensures that you have access to the best tools for advancing your research and achieving your scientific goals.

Please note that all services are for research use only. Not intended for any clinical use.

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