Gene: FLI1
Official Full Name: Fli-1 proto-oncogene, ETS transcription factorprovided by HGNC
Gene Summary: This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02617 | FLI1 Knockout cell line (HeLa) | Human | FLI1 | 1:3~1:6 | Negative | Online Inquiry |
FLI1 Gene Knockout Cell Lines are genetically modified cell models specifically engineered to silence the FLI1 gene, which encodes a key transcription factor implicated in various biological processes, including hematopoiesis, endothelial cell function, and tumorigenesis. These cell lines serve as essential tools for studying the functional role of FLI1 in both normal physiology and disease, providing insights into its regulatory mechanisms and involvement in cancer progression.
The primary function of FLI1 Gene Knockout Cell Lines is to facilitate research into the effects of FLI1 loss on cellular behavior. By employing CRISPR-Cas9 technology for precise gene editing, these cell lines allow researchers to evaluate changes in gene expression profiles, signaling pathways, and cellular characteristics such as proliferation, differentiation, and apoptosis. The specific knockout of the FLI1 gene aids in elucidating its contributions to oncogenic processes and vascular development, thereby enhancing our understanding of disorders associated with aberrant FLI1 activity.
In scientific research and clinical settings, FLI1 Gene Knockout Cell Lines are invaluable for drug discovery, disease modeling, and functional genomics. They facilitate the testing of therapeutic agents aimed at targeting the pathways regulated by FLI1 and enable the exploration of its role in a variety of cancers, including acute lymphoblastic leukemia and sarcomas. Moreover, the availability of these cell lines accelerates the screening of potential biomarkers for prognosis and treatment response.
Compared to alternative products, FLI1 Gene Knockout Cell Lines stand out due to their robust validation and reproducibility, ensuring reliable experimental outcomes. The specificity of the knockout achieved minimizes off-target effects, providing a clear focus on the gene's functional dynamics. Their efficiency when integrated into high-throughput screening applications further enhances their usefulness in large-scale studies.
As a product of our expertise in genetic engineering and biotechnology, FLI1 Gene Knockout Cell Lines reflect our commitment to advancing biological research and clinical applications. By offering cutting-edge tools that empower researchers and clinicians, we aim to support the scientific community in uncovering innovative solutions for complex medical challenges.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.