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FIBP Knockout Cell Lines

Gene: FIBP

Official Full Name: FGF1 intracellular binding proteinprovided by HGNC

Gene Summary: Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06827 FIBP Knockout cell line (HeLa) Human FIBP 1:3~1:6 Negative Online Inquiry
KO06828 FIBP Knockout cell line (HCT 116) Human FIBP 1:2~1:4 Negative Online Inquiry
KO06829 FIBP Knockout cell line (HEK293) Human FIBP 1:3~1:6 Negative Online Inquiry
KO06830 FIBP Knockout cell line (A549) Human FIBP 1:3~1:4 Negative Online Inquiry

Background

FIBP Gene Knockout Cell Lines represent a sophisticated tool for genetic research, facilitating the exploration of the biological functions associated with the fatty acid-binding protein (FIBP) gene. These cell lines are engineered to possess a targeted deletion of the FIBP gene, allowing researchers to study the phenotypic consequences and functional roles of FIBP in various cellular contexts. By eliminating gene expression, these cell lines serve as invaluable models for investigating lipid transport, metabolism, and related signaling pathways.

The mechanism behind FIBP Gene Knockout Cell Lines lies in gene editing technologies such as CRISPR-Cas9, which precisely disrupt the gene of interest, leading to a complete loss of FIBP protein expression. This alteration allows for in-depth analysis of metabolic processes and cellular behaviors that are directly influenced by the absence of FIBP, including fatty acid uptake and cellular responsiveness to lipid stimuli.

In research and clinical settings, understanding the role of FIBP is crucial, particularly in relation to metabolic disorders, obesity, and cardiovascular diseases. These knockout models provide insights into pathophysiological mechanisms, enabling the development of novel therapeutic strategies. Their versatility allows for applications ranging from basic research to drug discovery and development.

FIBP Gene Knockout Cell Lines offer unique advantages over traditional models, such as natural variability and non-targeted gene disruption. By providing a controlled loss-of-function approach, they enable more consistent and reproducible experimental outcomes. Furthermore, as highly characterized models, they save time and resources while reducing error margins in experimental design.

Researchers and clinicians seeking robust experimental platforms to elucidate gene function and explore therapeutic avenues will find these knockout cell lines essential. They represent a leap forward in understanding lipid metabolism at the molecular level.

Our company prides itself on pioneering innovative biological products that empower scientific discoveries. With a commitment to quality and specificity, we offer a range of gene knockout solutions that cater to the evolving needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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