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FHL2 Knockout Cell Lines

Gene: FHL2

Official Full Name: four and a half LIM domains 2provided by HGNC

Gene Summary: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00355 FHL2 gRNA5-gRNA6 KO plasmid FHL2 $850
KO37873 FHL2 Knockout cell line (HeLa) Human FHL2 1:3~1:6 Negative Online Inquiry
KO37874 FHL2 Knockout cell line (HCT 116) Human FHL2 1:2~1:4 Negative Online Inquiry
KO37875 FHL2 Knockout cell line (HEK293) Human FHL2 1:3~1:6 Negative Online Inquiry
KO37876 FHL2 Knockout cell line (A549) Human FHL2 1:3~1:4 Negative Online Inquiry

Background

FHL2 Gene Knockout Cell Lines are genetically engineered cell lines created to specifically disrupt the expression of the FHL2 gene, which encodes a multifunctional protein involved in various cellular processes, including cell differentiation, migration, and signaling pathways. By knocking out this gene, researchers can effectively study its role in health and disease, particularly in the context of cancer, cardiovascular diseases, and developmental disorders.

The primary function of these knockout cell lines is to facilitate the investigation of FHL2's biological effects. The mechanism involves the use of CRISPR/Cas9 or similar gene-editing technologies to induce targeted mutations in the FHL2 gene, resulting in the loss of its functional protein. Researchers can therefore evaluate changes in cellular behavior, gene expression profiles, and signaling mechanisms that occur as a result of FHL2 inactivation. This understanding is critical in deciphering the molecular underpinnings of diseases where FHL2 plays a pivotal role.

In terms of scientific importance, FHL2 Gene Knockout Cell Lines offer invaluable tools for both basic research and clinical applications. They enable investigators to elucidate the pathway dynamics that contribute to malignancies and other disorders, which can lead to the identification of potential therapeutic targets and biomarkers. Furthermore, these cell lines are indispensable for drug screening and development, as they provide a more accurate biological context than conventional cell lines.

One key advantage of FHL2 Gene Knockout Cell Lines is their specificity and reliability compared to alternative models, such as RNA interference or overexpression systems, which may yield less predictable results. Moreover, the ability to use these lines in different types of cells offers researchers flexibility and the potential to observe varying effects depending on tissue type or cellular context.

In a landscape where understanding gene function is crucial for advancing medical science, FHL2 Gene Knockout Cell Lines are an essential product for researchers and clinicians aiming to uncover novel insights and therapeutic strategies. Our company prides itself on delivering high-quality, rigorously tested biological products supported by a team of dedicated experts. We are committed to empowering scientific discovery and innovation through state-of-the-art gene-editing technologies.

Please note that all services are for research use only. Not intended for any clinical use.

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