Gene: FGFR4
Official Full Name: fibroblast growth factor receptor 4provided by HGNC
Gene Summary: The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10780 | FGFR4 Knockout cell line (HeLa) | Human | FGFR4 | 1:3~1:6 | Negative | Online Inquiry |
KO10781 | FGFR4 Knockout cell line (HCT 116) | Human | FGFR4 | 1:2~1:4 | Negative | Online Inquiry |
KO10782 | FGFR4 Knockout cell line (HEK293) | Human | FGFR4 | 1:3~1:6 | Negative | Online Inquiry |
KO10783 | FGFR4 Knockout cell line (A549) | Human | FGFR4 | 1:3~1:4 | Negative | Online Inquiry |
FGFR4 Gene Knockout Cell Lines are genetically engineered cell lines in which the fibroblast growth factor receptor 4 (FGFR4) gene has been inactivated through targeted genome editing techniques, such as CRISPR/Cas9. This innovative product provides researchers with an invaluable resource for studying the functional roles of FGFR4 in various biological processes, including cell proliferation, differentiation, and oncogenic pathways. FGFR4 is known for its significant involvement in various cancers, making these knockout cell lines crucial for elucidating the receptor's mechanisms in tumorigenesis.
The primary function of FGFR4 Gene Knockout Cell Lines is to facilitate the investigation of FGFR4 signaling and its implications in cancer biology. By eliminating FGFR4 expression, researchers can examine the resulting phenotypic changes and cellular behaviors that highlight the receptor's role. This approach allows for a direct assessment of FGFR4's contribution to cell signaling networks and its potential as a therapeutic target. Researchers can utilize these cell lines to test novel therapeutic compounds or gene therapies aimed at diseases associated with aberrant FGFR4 signaling.
The scientific importance of FGFR4 Gene Knockout Cell Lines is underscored by their applicability in both fundamental research and clinical investigations. They provide a platform for the exploration of drug resistance mechanisms and biomarker discovery, thereby enhancing the understanding of cancer biology and leading to the development of more effective treatment strategies. Compared to traditional cell lines, which may possess functional FGFR4, these knockout variants offer a more accurate model for studying the receptor's specific contributions without the confounding effects of its activity.
One of the standout advantages of our FGFR4 Gene Knockout Cell Lines is their reliability in providing consistent results across experiments. They are meticulously characterized and validated, ensuring that researchers can trust the data obtained from their studies. Moreover, our commitment to quality means that these cell lines are produced in compliance with stringent regulatory standards, offering users peace of mind regarding their experimental integrity.
For researchers, clinicians, and biopharmaceutical companies focusing on cancer therapies, FGFR4 Gene Knockout Cell Lines represent a pivotal tool that fosters innovative discoveries. By leveraging this product, users can accelerate their research efforts, leading to advancements that could significantly improve patient outcomes.
Our company, with extensive expertise in genetic engineering and cell line development, is dedicated to providing high-quality biological products that empower scientific discovery. With a strong focus on customer satisfaction and ongoing support, we are committed to facilitating your research and enhancing your capabilities in the field.
Please note that all services are for research use only. Not intended for any clinical use.
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